UA010829 HGFR/c-MET Fc Chimera Protein, Human
- 公司名稱 杭州斯達(dá)特生物科技有限公司
- 品牌 Starter/斯達(dá)特
- 型號(hào) UA010829
- 產(chǎn)地 江蘇 南京
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2025/7/17 7:38:10
- 訪問次數(shù) 37
聯(lián)系方式:王修明13774214275 查看聯(lián)系方式
聯(lián)系我們時(shí)請(qǐng)說明是化工儀器網(wǎng)上看到的信息,謝謝!
HGF R, also known as Met, is a glycosylated receptor tyrosine kinase that plays a pivotal role in epithelial morphogenesis and cancer development. It is synthesized as a single-chain precursor, which undergoes cotranslational proteolytic cleavage to form a mature HGFR. This mature receptor is a disulfide-linked dimer consisting of a 50 kDa extracellular alpha chain and a 145 kDa transmembrane beta chain. The extracellular domain (ECD) features a seven-bladed beta-propeller sema domain, a cysteine-rich PSI/MRS domain, and four Ig-like E-set domains. The cytoplasmic region contains the tyrosine kinase domain. HGFR is typically expressed by cells of epithelial origin, while HGF expression is limited to cells of mesenchymal origin.