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JAZF1抗體JAZF1主要參數(shù)>>>

中文名稱：  JAZF1抗體
英文名稱：  JAZF1
抗體別名：  JAZF zinc finger 1; JAZF1; JAZF1_HUMAN; Juxtaposed with another zinc finger protein 1; TAK1 interacting protein 27; TAK1-interacting protein 27; TIP27; Zinc finger protein 802; ZNF802.
抗體來源：  Rabbit
克隆類型：  Polyclonal
交叉反應：  Human，Mouse，Rat，Chicken，Pig，Horse，Rabbit，Sheep，
產(chǎn)品應用：  WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500
抗體濃度：  1mg/1ml
抗體性狀：  Lyophilized or Liquid
免 疫 原：   KLH conjugated synthetic peptide derived from human JAZF1
分 子 量：   27kDa
抗體亞型：  IgG
純化方法：  affinity purified by Protein A
細胞定位：  
研究領域：  
保存方法：
0.01M TBS(pH7.4) with 1% BSA， 0.03% Proclin300 and 50% Glycerol.
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹：
background:
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

Function:
Potential transcription factor.

Subunit:
Interacts with TAK1.

DISEASE:
Note=A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1.

Similarity:
Contains 3 C2H2-type zinc fingers.

Gene ID:
221895

Database links:

Entrez Gene: 221895 Human

Entrez Gene: 231986 Mouse

Entrez Gene: 685879 Rat

Omim: 606246 Human

SwissProt: Q86VZ6 Human

SwissProt: Q80ZQ5 Mouse

SwissProt: Q5RDF5 Orangutan

Unigene: 368944 Human

Unigene: 386865 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

II型糖尿病是危害很大的疾病，科學家們zui近又鑒定出了6個參與II型糖尿病有關的基因。其中JAZF1基因同時在II型糖尿病和前列腺癌中都起作用，但糖尿病和前列腺癌的變異處于基因的不同位置。這些研究將會幫助我們揭示復雜的糖尿病基礎，提示治療和預防這個疾病的更好新方法。{bios_back}{anti_back}{tongyogn_back}
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