S80008
具體成交價以合同協(xié)議為準
- 公司名稱 上海源葉生物科技有限公司
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- 廠商性質 生產廠家
- 更新時間 2025/5/14 20:35:58
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- 產品描述： Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
- 體內研究： Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa.Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study.Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10 mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal.
- 參考文獻：
1.Geboes K, et al. Pharmacology, 1993, 47 Suppl 1, 187-195. 2.Fioramonti J, et al. Pharmacology, 1993, 47 Suppl 1, 155-161. 3.Nishikawa J, et al. Arzneimittelforschung, 1981, 31(2), 321-325. 4.Tzavella K, et al. Eur J Gastroenterol Hepatol, 1995, 7(1), 13-20.
- 溶解度： Ethanol:3 mg/mL (6.23 mM) DMSO:89 mg/mL (184.9 mM) H2O:88 mg/mL (182.8 mM)
- 保存條件： -20℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.077 ml 10.386 ml 20.772 ml 5 mM 0.415 ml 2.077 ml 4.154 ml 10 mM 0.208 ml 1.039 ml 2.077 ml 50 mM 0.042 ml 0.208 ml 0.415 ml
- 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的性，僅供客戶參考交流研究之用。
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