S80087
具體成交價以合同協(xié)議為準
- 公司名稱 上海源葉生物科技有限公司
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- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2025/5/15 21:13:35
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- 產(chǎn)品描述： SRT 2104 是一種、高度選擇性、可通過血腦屏障的 Sirt1 (依賴于 NAD+) 激活劑，增加 Sirt1 蛋白水平，但對其 mRNA 無作用。用于糖尿病和亨廷頓氏癥的研究。
- 體內(nèi)研究： SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice.
SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice.
SRT 2104 (0.5%; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice.
- 參考文獻：
1: Baksi A, Kraydashenko O, Zalevkaya A, Stets R, Elliott P, Haddad J, Hoffmann E, Vlasuk GP, Jacobson EW. A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes. Br J Clin Pharmacol. 2014 Jul;78(1):69-77. doi: 10.1111/bcp.12327. PubMed PMID: 24446723; PubMed Central PMCID: PMC4168381.
2: van der Meer AJ, Scicluna BP, Moerlａnd PD, Lin J, Jacobson EW, Vlasuk GP, van der Poll T. The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans. Crit Care Med. 2015 Jun;43(6):e199-202. doi: 10.1097/CCM.0000000000000949. PubMed PMID: 25978169.
3: Sands BE, Joshi S, Haddad J, Freudenberg JM, Oommen DE, Hoffmann E, McCallum SW, Jacobson E. Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis. Inflamm Bowel Dis. 2016 Mar;22(3):607-14. doi: 10.1097/MIB.0000000000000597. PubMed PMID: 26595549; PubMed Central PMCID: PMC4885523.
4: Venkatasubramanian S, Noh RM, Daga S, Langrish JP, Joshi NV, Mills NL, Hoffmann E, Jacobson EW, Vlasuk GP, Waterhouse BR, Lang NN, Newby DE. Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers. J Am Heart Assoc. 2013 Jun 14;2(3):e000042. doi: 10.1161/JAHA.113.000042. PubMed PMID: 23770971; PubMed Central PMCID: PMC3698759.
- 溶解度： DMSO : 5 mg/mL (9.68 mM; Need ultrasonic)
H2O : < 0.1 mg l (insoluble)="">
- 保存條件： -20℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 1.936 ml 9.678 ml 19.356 ml 5 mM 0.387 ml 1.936 ml 3.871 ml 10 mM 0.194 ml 0.968 ml 1.936 ml 50 mM 0.039 ml 0.194 ml 0.387 ml
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