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化工儀器網(wǎng)>產(chǎn)品展廳>工業(yè)在線及過程控制儀>流量計流速儀/測漏儀>測漏儀> BPS Bioscience的AAV定制化服務

BPS Bioscience的AAV定制化服務

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  • 公司名稱 BPS Bioscience Inc.
  • 品牌 BPS Bioscience
  • 型號
  • 產(chǎn)地
  • 廠商性質(zhì) 生產(chǎn)廠家
  • 更新時間 2023/12/19 23:38:49
  • 訪問次數(shù) 378

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聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息,謝謝!


01
關(guān)于我們


BPS Bioscience是一家通過ISO 9001:2015認證的生命科學領(lǐng)域的供應商,公司一直致力于開發(fā)藥物研發(fā)領(lǐng)域的重組蛋白、檢測試劑盒、細胞系和慢病毒等工具。公司由Henry Zhu博士于2005年創(chuàng)立,從創(chuàng)立至今一直致力于提供藥物研發(fā)領(lǐng)域的創(chuàng)新解決方案,以推動新的藥物發(fā)現(xiàn)。公司主要關(guān)注的領(lǐng)域包括免疫療法、表觀遺傳學、病毒工具、CRISPR、細胞信號轉(zhuǎn)導等,BPS提供超過4500種高質(zhì)量研究工具,其中包括100多種特色產(chǎn)品。

BPS Bioscience一直保持在新品研發(fā)上的投入,公司平均每月推出20多種新產(chǎn)品。BPS Bioscience除了可以穩(wěn)定供應現(xiàn)貨產(chǎn)品外,也可接受客戶的多樣化的產(chǎn)品定制要求。此外,BPS Bioscience專業(yè)的技術(shù)團隊也提供所專注領(lǐng)域的生化和以細胞為基礎(chǔ)的檢測和化合物篩選服務。



02
歷史


BPS Bioscience成立之初主要提供市面上較為極少商業(yè)化的難以制造的重組蛋白、表觀遺傳學和細胞信號轉(zhuǎn)導相關(guān)的蛋白復合物。


隨后,這些功能性蛋白被用于多種檢測試劑盒的開發(fā),現(xiàn)在BPS Bioscience提供包括化學發(fā)光、比色、熒光、TR-FRET、熒光偏振和AlphaLISA ® 在內(nèi)的多種檢測試劑盒。目前,公司已將產(chǎn)品線延伸至到重組細胞系和慢病毒工具,以期進一步促進生化和細胞學研究。

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2021 年,為了進一步完善實驗室設(shè)施,BPS Bioscience 搬遷至位于加利福尼亞州圣地亞哥索倫托-梅薩生物技術(shù)中心區(qū)的 38,000 平方英尺的新實驗室,。

BPS Bioscience 的座口號是“科學家創(chuàng)立,科學家驅(qū)動”,公司一直致力于在滿足科學界不斷發(fā)展的需求。



03
我們的任務


BPS Bioscience 的使命是通過提供創(chuàng)新的解決方案來推進新的科學發(fā)現(xiàn),推動新的治療方法的面世。

我們專注于滿足新興研究需求,并以最快速度提供最新的解決方案。




04
質(zhì)量體系




BPS Bioscience專注于開發(fā)高質(zhì)量的產(chǎn)品,提供優(yōu)質(zhì)的客戶服務,并維護穩(wěn)健的質(zhì)量管理體系。BPS Bioscience現(xiàn)已通過ISO 9001:2015認證,確保質(zhì)量的持續(xù)監(jiān)控和持續(xù)改進,從而滿足客戶需求。

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05
以產(chǎn)品推動臨床前藥物發(fā)現(xiàn)



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BPS Bioscience產(chǎn)品涉及臨床前藥物開發(fā)過程的每個階段。其中部分產(chǎn)品可以用于許多研究階段。BPS Bioscience將繼續(xù)豐富我們的產(chǎn)品線,希望以此推動了整個早期藥物研發(fā)過程。





生物試劑

  • 提供商:

    BPS Bioscience

  • 服務名稱:

    BPS Bioscience的AAV定制化服務

Introduction

Adeno-Associated Viruses (AAV) are useful for gene therapy due to their gene transfer efficiency and safety. BPS Bioscience is developing a portfolio of AAV products to support your research needs. In addition, our custom services team will accelerate the design and production of your favorite AAV vectors.

Recombinant AAVs can be used in a Biosafety Level 1 (BSL-1) facility. Inside the cell, AAVs are episomal and can result in the sustained expression of a gene of interest for up to 6 months in non-dividing cells and up to 2 months in dividing cells HEK293.

AAV has at least 11 naturally-occurring serotypes. Each serotype shows preferential binding for specific cell types and tissues. Scientists can use this tropism to efficiently target specific cell types.

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Our AAV team will design your custom AAV constructs and will manufacture ready-for-use viral particles to transduce your gene(s) of interest. Applications include CRISPR-mediated genetic engineering, protein expression, and the design and optimization of AAV-mediated gene transfer using reporter AAVs.

Reporter gene

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CRISPR

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Gene of interest

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AAV Reporter Vectors

Reporter proteins, such as luciferase or fluorescent markers, are ideal to visualize and/or quantify gene expression following AAV transduction. Luciferase, ZsGreen, and mCherry-containing AAVs can be used to optimize transduction and experimental conditions, track transgene expression over time, or be used as internal controls. BPS Bioscience offers a selection of AAV Reporter vectors. If your ideal vector is not in the list, we can build it for you.

AAV Reporter Vectors Produce Robust Signals After Transduction

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A: 4-20% SDS-PAGE gel staining showing purified AAV1-ZsGreen particles. The protein ladder is in lane 1 and AAV1 is in lane 2. The gel was stained using One-Step Lumitein™ UV Protein Gel Stain (Biotium) and imaged using the used an ethidium bromide filter. The image was reversed to show protein bands in black.

B: Transduction of HEK293 cells using AAV1-ZsGreen. Expression of ZsGreen in the target cells was observed under a fluorescence microscope 72 hours after transduction. ZsGreen expression was stable over time and still observed 30 days after transduction.

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A: Transduction of HEK293 cells with an AAV-Luciferase. Luciferase activity was measured using the ONE-Step™ Luciferase Assay System (BPS Bioscience #60690) 72 hours after transduction.

B: Transduction of HEK293 cells with an AAV-mCherry. The expression of mCherry was observed under a fluorescence microscope 72 hours after transduction.

CRISPR/Cas9 AAV Vectors

Cas9 is an endonuclease enzyme that is recruited to a specific DNA sequence by the sgRNA (single guide RNA) to introduce a double stranded break into the DNA. In mammalian cells this break is repaired either through Non-Homologous End Joining (NHEJ) or Homologous Recombination. NHEJ often results in the deletion or insertion of several base pairs at the cut site, which, when resulting in a frameshift, causes the functional inactivation of the gene.

SaCas9 (Staphylococcus aureus CRISPR associated protein 9) has demonstrated high cutting efficiency in mammalian cells, and its smaller size makes it ideal for packaging into AAV. These AAV-SaCas9 vectors are used to generate a SaCas9 over-expressing cell line for knockout or knock-in studies.

We also offer custom AAV production services to package the AAV-SaCas9 with your gene-specific sgRNA in the same virions.

圖片
Transduction of HEK293 cells using an AAV-SaCas9.
Cells were transduced with AAV-Cas9 virions at an
MOI of 1 x 104. 72 hours after transduction, SaCas9
expression in the target cells were detected by
Western blot with an anti-HA.11 antibody. GAPDH
was used as a loading control.


如果您需要了解更多關(guān)于我們的服務的信息,請聯(lián)系info。



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