Z03367 TRAIL, Mouse
| 參考價 | ￥534.00 |
具體成交價以合同協(xié)議為準
- 公司名稱 漠寶（廈門）生物科技有限公司
- 品牌GenScript/金斯瑞
- 型號Z03367
- 所在地廈門市
- 廠商性質代理商
- 更新時間2025/5/22 8:56:51
- 訪問次數(shù) 81
規(guī)格
| 50 μg | 534.00元 | 14 件可售 |
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| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 50 μg |
|---|---|---|---|
| 貨號 | Z03367 | 應用領域 | 醫(yī)療衛(wèi)生,食品/農產品,化工,生物產業(yè),制藥/生物制藥 |
TNF-related apoptosis-inducing ligand (TRAIL), also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10) or apoptosis 2 ligand (Apo2L), is a pleiotropic cytokine thatbelongs to the TNF superfamily.
產品簡介
| Species | Mouse | |
| Protein Construction | Expressed with an N-terminal Gly.
| |
| Purity | > 98% as analyzed by SDS-PAGE | |
| Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
| Biological Activity | ED50 < 100.0 ng/ml, measured by the cell growth inhibitory assay using RPMI-8226 cells, corresponding to a specific activity of > 1.0 × 104 units/mg. | |
| Expression System | E. coli | |
| Apparent Molecular Weight | ~20 kDa, on SDS-PAGE under reducing conditions. | |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
圖例
技術背景
| Target Background | TNF-related apoptosis-inducing ligand (TRAIL), also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10) or apoptosis 2 ligand (Apo2L), is a pleiotropic cytokine thatbelongs to the TNF superfamily. Full length TRAIL expressed in vivo is a type II transmembrane protein, although the soluble form also exists and functions. TRAIL has four major receptors: two death receptors DR4 and DR5, and two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors which recruits the FAS-associated death domain and activates caspases 8 and 10 which eventually leads to apoptosis. Because of its antitumor potential, TRAIL is activelystudied as a therapeutic agent. On the other hand, abnormal expression of TRAIL in small arteries can induce the proliferation of smooth muscle cells, thereby increasing vascular remodeling and pulmonary arterial hypertension. |
| Synonyms | Tumor necrosis factor ligand superfamily member 10; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253; Tnfsf10 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
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