UA040088 AITRL Protein, Mouse
- 公司名稱(chēng) 杭州斯達(dá)特生物科技有限公司
- 品牌 Starter/斯達(dá)特
- 型號(hào) UA040088
- 產(chǎn)地 江蘇 南京
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2025/7/16 8:14:11
- 訪問(wèn)次數(shù) 64
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Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-induced tumor necrosis factor receptor (TNFR) family-related protein (GITR), is a type I transmembrane protein that belongs to the TNF receptor superfamily. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. GITR-GITRL cross-linking costimulated native and activated T cells and resulted in MAPK activation. Researches have indicated that GITRL could promote Th17 cell differentiation by p38 MAPK and STAT3 signaling in autoimmune arthritis.