UA040098 NELFE Protein, Human
- 公司名稱(chēng) 杭州斯達(dá)特生物科技有限公司
- 品牌 Starter/斯達(dá)特
- 型號(hào) UA040098
- 產(chǎn)地 江蘇 南京
- 廠(chǎng)商性質(zhì) 生產(chǎn)廠(chǎng)家
- 更新時(shí)間 2025/8/11 8:47:12
- 訪(fǎng)問(wèn)次數(shù) 52
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Negative elongation factor E (NELFE) is part of a complex termed NELF which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). Further mechanistic studies revealed that NELFE activates the Wnt/β?catenin signaling pathway by decreasing the stabilization of NDRG2 mRNA in pancreatic cancer. oncogenic activation of NELFE promotes hepatocellular carcinoma (HCC) cell proliferation and predicts the strong metastatic potential of HCC cells.