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化工儀器網>產品展廳>試劑標物>生化試劑>蛋白質/多肽>UA040015 IL-1β Protein, Human

UA040015 IL-1β Protein, Human

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杭州斯達特是一家集研發(fā)、生產、銷售與技術服務為一體的高科技生物公司,志在為全球生物醫(yī)學研究、體外診斷企業(yè)、生物制藥企業(yè)提供優(yōu)質的抗體、蛋白、試劑盒和定制服務,包括科研抗體、CDx和IVD抗原和抗體原料、一步法ELISA試劑盒、鼠兔通用二抗試劑盒以及其他用途的免疫試劑整體解決方案。


公司核心團隊深耕抗體研發(fā)十五年,具有成功開發(fā)數千種精準醫(yī)學抗體、科研抗體的豐富經驗。公司建立了多物種單B細胞抗體開發(fā)平臺(兔單抗,鼠類單抗等)、傳統(tǒng)鼠單抗、重組蛋白表達平臺及完善的抗體應用驗證和檢測體系(包括免疫層析,酶聯免疫,流式分析,免疫組化,免疫印跡,免疫熒光,免疫沉淀等)。已正式通過歐盟98/79/EC認證、ISO9001認證和ISO13485認證。


公司以加速人類、疾病診斷、為人類和動物健康保駕護航為使命,以扎實的科學技術為基礎,秉承向正向善向上的價值觀,以行業(yè)客戶需求為導向,愿與全球同仁精誠合作,共啟健康新篇章。


斯達特,專注于抗體研發(fā)和制造,您的最佳抗體優(yōu)選伙伴。

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Interleukin-1β (IL-1β) is a major cytokine involved in monocyte activation and activation of proinflammatory signaling pathways in peripheral tissues and brain. IL-1β expression and its secretion are tightly regulated. IL-1β is released by several cell types, including activated macrophages, monocytes, and cells within the hypothalamus, where it can stimulate its own expression.IL-1β is present and active in the luteinized ovary as shown by its expression in human granulosa lutein cells and in follicular fluid macrophages that are natural components of the corpus luteum tissue. IL-1β, its corresponding receptor antagonist Interleukin Receptor Antagonist-1 (IL-1RA), and Interleukin 1 alpha (IL-1α) are encoded by the genes IL-1B, IL-1RN, and IL-1A respectively, as constituents of the Interleukin 1 (IL-1) gene cluster. IL-1β is a crucial candidate due to its dual role as both a proinflammatory signaling molecule and an inhibitor of gastric acid secretion. IL-1β can promote tumor growth, but also antitumor activities. The presence of IL-1β and other inflammatory cytokines also has been noted at an early phase of plaque formation in the brains of patients with Alzheimer's disease.



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