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化工儀器網(wǎng)>產(chǎn)品展廳>試劑標物>生化試劑>蛋白質(zhì)/多肽>UA040008 IL-3 Protein, Human

UA040008 IL-3 Protein, Human

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  • 公司名稱 杭州斯達特生物科技有限公司
  • 品牌 Starter/斯達特
  • 型號 UA040008
  • 產(chǎn)地 江蘇 南京
  • 廠商性質(zhì) 生產(chǎn)廠家
  • 更新時間 2025/7/16 11:45:46
  • 訪問次數(shù) 45

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杭州斯達特是一家集研發(fā)、生產(chǎn)、銷售與技術服務為一體的高科技生物公司,志在為全球生物醫(yī)學研究、體外診斷企業(yè)、生物制藥企業(yè)提供優(yōu)質(zhì)的抗體、蛋白、試劑盒和定制服務,包括科研抗體、CDx和IVD抗原和抗體原料、一步法ELISA試劑盒、鼠兔通用二抗試劑盒以及其他用途的免疫試劑整體解決方案。


公司核心團隊深耕抗體研發(fā)十五年,具有成功開發(fā)數(shù)千種精準醫(yī)學抗體、科研抗體的豐富經(jīng)驗。公司建立了多物種單B細胞抗體開發(fā)平臺(兔單抗,鼠類單抗等)、傳統(tǒng)鼠單抗、重組蛋白表達平臺及完善的抗體應用驗證和檢測體系(包括免疫層析,酶聯(lián)免疫,流式分析,免疫組化,免疫印跡,免疫熒光,免疫沉淀等)。已正式通過歐盟98/79/EC認證、ISO9001認證和ISO13485認證。


公司以加速人類、疾病診斷、為人類和動物健康保駕護航為使命,以扎實的科學技術為基礎,秉承向正向善向上的價值觀,以行業(yè)客戶需求為導向,愿與全球同仁精誠合作,共啟健康新篇章。


斯達特,專注于抗體研發(fā)和制造,您的最佳抗體優(yōu)選伙伴。

抗體,蛋白,試劑盒

IL-3 (also known as multispecific hemopoietin) is naturally produced by both Th1 and Th2 lymphocytes, mast cells, and eosinophils. IL-3 stimulates the production of macrophages, granulocytes, and dendritic cells from bone marrow precursors. The IL-3 is involved in bone marrow hemopoiesis and dendritic cell maturation in anti-viral or antitumor reactivity. IL-3 binds with high affinity to the IL-3 receptor α (IL-3Rα/CD123) and then associates with the βc subunit. IL-3 is the most important growth and activating factor for human and mouse basophils, primary effector cells of allergic disorders. IL-3-activated basophils and mast cells are also involved in different chronic inflammatory disorders, infections, and several types of cancer. IL-3 induces the release of cytokines (i.e., IL-4, IL-13, CXCL8) from human basophils and preincubation of basophils with IL-3 potentiates the release of proinflammatory mediators and cytokines from IgE and C5a-activated basophils. IL-3 synergistically potentiates IL-33-induced mediator release from human basophils. IL-3 plays a pathogenic role in several hematologic cancers and may contribute to autoimmune and cardiac disorders.IL-3Rα/CD123 is also highly expressed on human plasmacytoid DCs, making IL-3 a crucial survival factor for the rare blastic plasmacytoid DC neoplasm (BPDCN). IL-3 supports the proliferation of mouse and human B cells. IL-3 and GM-CSF stimulate the adhesion of human monocytes to endothelial cells. Human endothelial cells are an important target of IL-3. IL-3 activates IL-3 receptor and the proliferation of human endothelial cells and promotes in vivo vessel formation. The proangiogenic activity of IL-3 could contribute to its role in cancer initiation and progression. IL-3 is a growth factor for microglia and modulates mouse and human neurons. Finally, IL-3 regulates bone homeostasis through the modulation of osteoblast differentiation.



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