UA040208 IL-36α Protein, Human
- 公司名稱 杭州斯達特生物科技有限公司
- 品牌 Starter/斯達特
- 型號 UA040208
- 產(chǎn)地 江蘇 南京
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2025/7/16 12:26:23
- 訪問次數(shù) 38
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Interleukin-36 (IL-36) is part of the larger IL-1 family of cytokines and includes three agonists, IL-36α, IL-36β and IL-36γ, and two inhibitors, IL-36RA and IL-38. IL-36α is proteolytically cleaved to its active form, primarily by neutrophil proteases, yielding an active cytokine. IL-36Ra is the antagonist that is specific for IL-36α, β, γ and does this by binding to ILRrp2, in an analogous way to IL-1Ra inhibition of IL-1β. IL-36 signalling activates mitogen-activated protein kinases (MAPKs) and NF-KB resulting in downstream target gene activation. IL-36 signals through the IL-36 Receptor and its co-receptor IL1R accessory protein is necessary for downstream signalling. IL-36α functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this protein has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients.