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化工儀器網(wǎng)>產(chǎn)品展廳>試劑標(biāo)物>生化試劑>蛋白質(zhì)/多肽>UA040212 DHH Protein, Human

UA040212 DHH Protein, Human

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  • 公司名稱(chēng) 杭州斯達(dá)特生物科技有限公司
  • 品牌 Starter/斯達(dá)特
  • 型號(hào) UA040212
  • 產(chǎn)地 江蘇 南京
  • 廠商性質(zhì) 生產(chǎn)廠家
  • 更新時(shí)間 2025/8/11 13:27:15
  • 訪問(wèn)次數(shù) 61

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杭州斯達(dá)特是一家集研發(fā)、生產(chǎn)、銷(xiāo)售與技術(shù)服務(wù)為一體的高科技生物公司,志在為全球生物醫(yī)學(xué)研究、體外診斷企業(yè)、生物制藥企業(yè)提供優(yōu)質(zhì)的抗體、蛋白、試劑盒和定制服務(wù),包括科研抗體、CDx和IVD抗原和抗體原料、一步法ELISA試劑盒、鼠兔通用二抗試劑盒以及其他用途的免疫試劑整體解決方案。


公司核心團(tuán)隊(duì)深耕抗體研發(fā)十五年,具有成功開(kāi)發(fā)數(shù)千種精準(zhǔn)醫(yī)學(xué)抗體、科研抗體的豐富經(jīng)驗(yàn)。公司建立了多物種單B細(xì)胞抗體開(kāi)發(fā)平臺(tái)(兔單抗,鼠類(lèi)單抗等)、傳統(tǒng)鼠單抗、重組蛋白表達(dá)平臺(tái)及完善的抗體應(yīng)用驗(yàn)證和檢測(cè)體系(包括免疫層析,酶聯(lián)免疫,流式分析,免疫組化,免疫印跡,免疫熒光,免疫沉淀等)。已正式通過(guò)歐盟98/79/EC認(rèn)證、ISO9001認(rèn)證和ISO13485認(rèn)證。


公司以加速人類(lèi)、疾病診斷、為人類(lèi)和動(dòng)物健康保駕護(hù)航為使命,以扎實(shí)的科學(xué)技術(shù)為基礎(chǔ),秉承向正向善向上的價(jià)值觀,以行業(yè)客戶需求為導(dǎo)向,愿與全球同仁精誠(chéng)合作,共啟健康新篇章。


斯達(dá)特,專(zhuān)注于抗體研發(fā)和制造,您的最佳抗體優(yōu)選伙伴。

抗體,蛋白,試劑盒

Desert Hedgehog (Dhh) belongs to the highly conserved Hedgehog family of proteins which are involved in multiple developmental processes. Hedgehogs are synthesized as 45 kDa precursors that are cleaved autocatalytically. The 19 kDa N-terminal fragment remains membrane associated due to its cholesterol and palmitate modifications. Binding of this fragment to Patched receptors results in the loss of Patched repression of Smoothened signaling. Dhh binds both Patched and Patched 2 as well as Hedgehog interacting protein (Hip). Within the N-terminal peptide, mouse Dhh shares 97% and 100% amino acid (aa) sequence identity with human and rat Dhh, respectively. It shares 74% aa seqeuence identity with mouse Indian (Ihh) and Sonic hedgehog (Shh). Dhh is produced by Sertoli cells and is required for testis development and spermatogenesis. It induces steroidogenic factor 1 which is instrumental in promoting Leydig cell differentiation. It also promotes the deposition of basal lamina surrounding seminiferous tubules. In humans, mutations of Dhh are associated with pure gonadal dysgenesis. Dhh is expressed in the female by ovarian granulosa cells and the corpus luteum. Its upregulation in human ovarian cancer correlates positively with proliferative index and negatively with prognosis. Dhh is also expressed by Schwann cells and is upregulated following nerve injury. It induces the expression of Patched and Hip in nerve fibroblasts and promotes the formation of the connective tissue sheath surrounding peripheral nerves.

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