UA040215 IL-36Rα Protein, Human
- 公司名稱(chēng) 杭州斯達(dá)特生物科技有限公司
- 品牌 Starter/斯達(dá)特
- 型號(hào) UA040215
- 產(chǎn)地 江蘇 南京
- 廠(chǎng)商性質(zhì) 生產(chǎn)廠(chǎng)家
- 更新時(shí)間 2025/7/16 13:06:18
- 訪(fǎng)問(wèn)次數(shù) 32
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The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory protein (IL-1RAcP). The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. Assembled ternary complex brings together intracellular TIR domains of receptors which activate downstream NF-κB and MAPK signaling. Antagonist IL-36Ra inhibits the signaling by binding to IL-36R and preventing recruitment of IL-1RAcP.