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化工儀器網(wǎng)>產(chǎn)品展廳>試劑標(biāo)物>生化試劑>蛋白質(zhì)/多肽>UA040278 BAFF Protein, Mouse

UA040278 BAFF Protein, Mouse

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  • 公司名稱 杭州斯達(dá)特生物科技有限公司
  • 品牌 Starter/斯達(dá)特
  • 型號(hào) UA040278
  • 產(chǎn)地 江蘇 南京
  • 廠商性質(zhì) 生產(chǎn)廠家
  • 更新時(shí)間 2025/7/16 17:07:28
  • 訪問(wèn)次數(shù) 44

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杭州斯達(dá)特是一家集研發(fā)、生產(chǎn)、銷售與技術(shù)服務(wù)為一體的高科技生物公司,志在為全球生物醫(yī)學(xué)研究、體外診斷企業(yè)、生物制藥企業(yè)提供優(yōu)質(zhì)的抗體、蛋白、試劑盒和定制服務(wù),包括科研抗體、CDx和IVD抗原和抗體原料、一步法ELISA試劑盒、鼠兔通用二抗試劑盒以及其他用途的免疫試劑整體解決方案。


公司核心團(tuán)隊(duì)深耕抗體研發(fā)十五年,具有成功開(kāi)發(fā)數(shù)千種精準(zhǔn)醫(yī)學(xué)抗體、科研抗體的豐富經(jīng)驗(yàn)。公司建立了多物種單B細(xì)胞抗體開(kāi)發(fā)平臺(tái)(兔單抗,鼠類單抗等)、傳統(tǒng)鼠單抗、重組蛋白表達(dá)平臺(tái)及完善的抗體應(yīng)用驗(yàn)證和檢測(cè)體系(包括免疫層析,酶聯(lián)免疫,流式分析,免疫組化,免疫印跡,免疫熒光,免疫沉淀等)。已正式通過(guò)歐盟98/79/EC認(rèn)證、ISO9001認(rèn)證和ISO13485認(rèn)證。


公司以加速人類、疾病診斷、為人類和動(dòng)物健康保駕護(hù)航為使命,以扎實(shí)的科學(xué)技術(shù)為基礎(chǔ),秉承向正向善向上的價(jià)值觀,以行業(yè)客戶需求為導(dǎo)向,愿與全球同仁精誠(chéng)合作,共啟健康新篇章。


斯達(dá)特,專注于抗體研發(fā)和制造,您的最佳抗體優(yōu)選伙伴。

抗體,蛋白,試劑盒


TNFSF13B/TNFSF20 belongs to the tumor necrosis factor family. It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3 acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors. Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD, human BAFF shares 72% aa sequence identity with mouse BAFF.


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