產(chǎn)品描述

在生命科學(xué)、基礎(chǔ)醫(yī)學(xué)及高原生理等研究領(lǐng)域，精確模擬低氧環(huán)境對于探究缺氧對動(dòng)物機(jī)體的影響至關(guān)重要。低氧工作站正是為此類嚴(yán)謹(jǐn)動(dòng)物實(shí)驗(yàn)而設(shè)計(jì)的核心設(shè)備。

不同于普通低氧實(shí)驗(yàn)箱在操作時(shí)必須開箱破壞環(huán)境，低氧工作站通過其全密閉結(jié)構(gòu)和內(nèi)置操作手套，實(shí)現(xiàn)了革命性的突破。研究者無需打開主腔室，即可通過氣密手套在持續(xù)、穩(wěn)定維持目標(biāo)低氧水平（如1%-21% O?可調(diào)）的環(huán)境下，對箱內(nèi)動(dòng)物進(jìn)行各項(xiàng)操作，包括：

?日常照料：安全地進(jìn)行喂食、飲水更換，確保動(dòng)物長期實(shí)驗(yàn)中的基本生存需求。

?實(shí)驗(yàn)干預(yù)：執(zhí)行精準(zhǔn)的給藥、注射、手術(shù)或生理參數(shù)監(jiān)測（如體溫、心率）。

?行為觀察：在恒定低氧條件下進(jìn)行動(dòng)物行為學(xué)實(shí)驗(yàn)，減少環(huán)境波動(dòng)干擾。

?原位采樣：直接在低氧環(huán)境中采集血液、組織等樣本，很大程度避免樣本暴露于常氧環(huán)境導(dǎo)致的氧化應(yīng)激或代謝狀態(tài)改變，保障后續(xù)分析數(shù)據(jù)的真實(shí)性。

?設(shè)備操作：放置或操作小型實(shí)驗(yàn)儀器（如微型跑步機(jī)、攝像頭）。

核心優(yōu)勢

1、環(huán)境穩(wěn)定性：操作過程“零中斷”低氧環(huán)境，氧氣濃度波動(dòng)極小（通常<±0.1%），為慢性、長期低氧暴露實(shí)驗(yàn)（數(shù)天至數(shù)月）提供持續(xù)、可靠的低氧條件，消除因頻繁開箱導(dǎo)致的濃度回升與恢復(fù)延遲問題。

2、操作便利性與連續(xù)性：無需等待環(huán)境恢復(fù)，可隨時(shí)、頻繁地進(jìn)行實(shí)驗(yàn)操作，極大提升實(shí)驗(yàn)效率和靈活性。

3、減少動(dòng)物應(yīng)激：密閉操作減少了光線、噪音和人員活動(dòng)對動(dòng)物的直接干擾，有助于獲得更接近自然狀態(tài)的生理反應(yīng)數(shù)據(jù)。

4、保障樣本真實(shí)性：低氧環(huán)境下的原位采樣和處理，是研究缺氧相關(guān)生物標(biāo)志物、基因表達(dá)和代謝產(chǎn)物的關(guān)鍵保障，避免取樣后氧化造成的假象。

5、集成環(huán)境控制（可選）：高級型號可集成精確的溫濕度控制系統(tǒng)及CO?清除裝置，為動(dòng)物提供更舒適、生理狀態(tài)更穩(wěn)定的實(shí)驗(yàn)環(huán)境。

6、潔凈度與安全性：密閉設(shè)計(jì)結(jié)合高效過濾系統(tǒng)（HEPA/ULPA），可有效控制微生物污染；同時(shí)為操作者提供物理屏障，隔絕潛在過敏原或?qū)嶒?yàn)性有害物質(zhì)。

應(yīng)用場景

低氧工作站是進(jìn)行高原適應(yīng)機(jī)制研究、缺血性疾病模型、低氧相關(guān)腫瘤研究、低氧與代謝疾病的研究、低氧與心血管疾病的研究、圍生期缺血缺氧性腦損傷以及任何要求在穩(wěn)定低氧環(huán)境下進(jìn)行活體操作或原位取樣的動(dòng)物實(shí)驗(yàn)的理想平臺(tái)。它克服了傳統(tǒng)低氧箱的核心局限，為獲得嚴(yán)謹(jǐn)、可重復(fù)的高質(zhì)量科研數(shù)據(jù)奠定了堅(jiān)實(shí)的基礎(chǔ)。

技術(shù)參數(shù)

1. 為動(dòng)物低氧實(shí)驗(yàn)?zāi)Ｐ偷慕⑻峁┓€(wěn)定的低氧環(huán)境

2. 按照設(shè)定氣體濃度自動(dòng)配比氣體，維持恒定的氧氣濃度環(huán)境。無需在箱體外混合比例氣體，實(shí)驗(yàn)氧濃度的準(zhǔn)確，節(jié)省氣源

3. 觸摸屏控制，人性化界面，操作簡單

4. 監(jiān)測參數(shù)：溫度、濕度、氧氣濃度、二氧化碳濃度

5. 控制精度：±0.1%

6. 非色散紅外（NDIR）二氧化碳傳感器，測量范圍：0～5000ppm

7. 進(jìn)口電化學(xué)氧氣濃度檢測器，測量范圍：0-25%vol（可選配0.1-99.0%），線性度好，檢測準(zhǔn)確、使用壽命長。具有溫度補(bǔ)償機(jī)制

8. 溫度檢測：進(jìn)口高精度溫度傳感器

9. 氧氣濃度變化動(dòng)態(tài)曲線，直觀了解氧氣濃度變化的過程

10. 內(nèi)置紫外滅菌燈，可定時(shí)滅菌

11. 具有定時(shí)功能，實(shí)驗(yàn)完成，自動(dòng)恢復(fù)常氧狀態(tài)，并伴有聲音提示

12. 氧氣濃度自動(dòng)校準(zhǔn)：通過控制器對傳感器快速校準(zhǔn)

13.氣體混合及循環(huán)機(jī)制，保證箱體內(nèi)氣體濃度的均一

14. 高性能電磁閥，性能穩(wěn)定，超長壽命

15. 前面板可徒手拆卸，便于放置設(shè)備

可選配功能

1、溫度濕度控制功能，控溫范圍：室溫+3~45℃（可選4~45℃），調(diào)節(jié)精度0.1℃；濕度40~85%RH

2、遠(yuǎn)程監(jiān)控：可通過電腦、手機(jī)遠(yuǎn)程監(jiān)控實(shí)驗(yàn)運(yùn)行狀態(tài)，具有可夜視紅外攝像頭

3、二氧化碳吸附裝置

4、二氧化碳濃度控制功能，可設(shè)定目標(biāo)濃度，控制范圍：0-20.0%，其他范圍可選

型號選擇

相關(guān)文獻(xiàn)

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[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling".[J]. Archives of Biochemistry and Biophysics ,Volume 729,109393.

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice:Involvement of inhibition of the NF-κB signaling pathway in glial cells".[J].European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei,Miao-Yue Hu,Xiu-Qi Chen,Feng-Ying Lei,Jin-Shuang Wei,Jie Chen,Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J]. European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei,Sijing Zhao,Nan Jia, Demei Huang, Xiaomin Wang,Yongcan Wu, Shihua Shi,Yacong He,Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling".[J].Biomedicine & Pharmacotherapy,Volume 156,2022,113982.

[6]Fang Zhao, Yan Meng,Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway".[J].Frontiers in Pharmacology,10.3389/fphar.2022.920977.[7]Xu Y, Kong X, Li J, Cui T, Wei Y, Xu J,Zhu Y, Zhu X."Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys."[J]. Front. Physiol. 12:690496.doi: 10.3389/fphys.2021.690496.

[8]Liang Xie, Qinhan Wu, Weiping Hu, Xu Wu, Guiling Xiang, Shengyu Hao, Han Guo, Shanqun Li."Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions."[J].Psychopharmacology.

[9]Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi. "Hypoxia Improves Endurance Performance by Enhancing Short Chain Fatty Acids Production via Gut Microbiota Remodeling."[J].Front. Microbiol. 12:820691.

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Zhang,C.,Sun,Y.,Guo,Y.et al."JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension."[J].Cell Death Discov.9, 98(2023).

[12]Fang Zhao,Yan Meng, Yue Wang, Siqi Fan,Yu Liu,Xiangfeng Zhang,Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway".[J].Frontiers in Pharmacology,10.3389/fphar.2022.920977.

[13]Chenyu Xu,Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."[J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324,15 pages.

[14]Jing Zhang, Jian-Zhong Jiang, Jun Xu, Chen-Yu Xu,Shan Mao, Ying Shi, Wei Gu, Chun-Fang Zou, Yue-Ming Zhao,Liang Ye."Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea." [J].Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

[15]Zhang Q, Xu L, Bai Y, Chen P, Xing M, Cai F, Wu Y,Song W."Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation."[J]. Front.Mol.Neurosci.16:1155047.

[16]Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao."JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension."[J]. Cell Death Discovery (2023) 9:98.

[17]Chen-Yu Jiang,Li-Wei Wu,Yi-Wei Liu,Bei Feng, Lin-Cai Ye,Xu Huang,Yang-Yang He,Yi Shen, Yi-Fan Zhu, Xing-Liang Zhou, Dai-Ji Jiang, Hai-Kun Qi, Hao Zhang, and Yi Yan.Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension,[J]Frontiers in?Immunology,28 June 2023,Volume 14 - 2023,DOI:10.3389/fimmu.2023.1153573.

[18]Haimei Lun, Ruochuan Liu, Qiao Hu, Yaoli Liu, Lisi Wei, Xia Liu, Dan Wu, Shangyong Zhu,Contrast?Enhanced?Ultrasonography?of?Kidney?in?Chronic?Intermittent?Hypoxia?Rat?Model,[J]Journal of Ultrasound in Medicine,2022-12-07 ,DOI:10.1002/jum.16147.

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