點擊化學(xué)利用四嗪碳納米管實現(xiàn)靶向成像

利用TCO和Tz之間的正交切割反應(yīng)，把Tz搭載于靶向性的納米材料單壁碳納米管SWCNTs上（Tz@SWCNTs），實現(xiàn)對預(yù)靶向。其主要原理：利用通透性增與滯留效應(yīng)，使Tz@SWCNTs在組織中積累。通過TCO分子或探針，由在富集的Tz進行正交切割。

通過研究tAMC與Tz@SWCNTs之間的釋放動力學(xué)，相比于mTZ小分子，Tz@SWCNTs對tAMC的衰減反應(yīng)性，且能在下，對MCF-7進行靶向并tAMC熒光。

將陽離子染料半菁HCA和TCO相連得到近紅外熒光探針tHCA用于通過生物正交釋放反應(yīng)的近紅外熒光探針。該探針在下因Tz@SWCNTs的激發(fā)釋放，并在720nm下發(fā)出熒光。

瑞禧相關(guān)產(chǎn)品：

Tetrazine-NHS Ester

Methyltetrazine-NHS Este

Tetrazine-Sulfo-NHS Ester

Methyltetrazine-Sulfo-NHS Ester

Tetrazine-PEG5-NHS Ester

Methyltetrazine-PEG4-NHS Ester

Methyltetrazine-PEG5-NHS Ester

Methyltetrazine-PEG4-Sulfo-NHS Ester

Methyltetrazine-Acid

Tetrazine-Acid

Methyltetrazine-PEG4-Acid

PC Methyltetrazine-NHS Ester

R-CT-013 Methyltetrazine-Amine

Tetrazine-Amine

Methyltetrazine-Propylamine

Methyltetrazine-PEG4-Amine

Methyltetrazine-PEG4-Maleimide

Bis-sulfone-PEG4-Tetrazine

ThioLinker-Tetrazine

Methyltetrazine-DBCO

Methyltetrazine-PEG12-DBCO

Methyltetrazine-PEG4-Alkyne

Methyltetrazine-PEG4-Azide

Methyltetrazine-mPEG,5 kDa

Methyltetrazine-mPEG, 10 kDa

Methyltetrazine-mPEG, 20 kDa

Methyltetrazine-mPEG, 30 kDa

Biotin-PEG4-Methyltetrazine

Cy3 Tetrazine

Cy3 Methyltetrazine