hCDH6/4T1 hCDH6/4T1 hCDH6/4T1
| I. Background | |||
| CDH6 （Cadherin 6,鈣粘蛋白 6）是一種 II 型鈣粘附素，是鈣粘附素家族的成員之一。 CDH6 對于細胞黏附、胚胎發(fā)育的細胞識別、遷移和組織分化、構成成體器官都有重要作 用。在胚胎發(fā)育過程中，參與胚胎腎形態(tài)形成和發(fā)育，驅(qū)動腎形態(tài)發(fā)生所需的間充質(zhì)-上皮 分化。CDH6 在甲狀腺腫瘤、膽管癌、骨肉瘤、口腔鱗狀細胞癌、黑色素瘤、甲狀腺乳頭 狀癌、鼻咽癌、膠質(zhì)瘤、胃癌等腫瘤中起到重要作用。CDH6 還可以作為甘氨酰-tRNA 合 成酶（GRS）的功能性受體在人體內(nèi)部起到抗腫瘤作用。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hCDH6 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+2μg/ml puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
Figure 1. Recombinant hCDH6/4T1 stably expressing CDH6. | |||
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