依魯替尼雜質(zhì)長(zhǎng)期備有庫(kù)存

時(shí)間：2017-2-8閱讀：1819

依魯替尼雜質(zhì)為深圳遠(yuǎn)揚(yáng)化學(xué)技術(shù)有限公司優(yōu)勢(shì)雜質(zhì)，長(zhǎng)期備有庫(kù)存，申報(bào)可用，隨貨提供COA證書(shū)，氫譜，質(zhì)譜及HPLC，純度符合申報(bào)要求，質(zhì)量保證。更多雜質(zhì)對(duì)照品，歡迎進(jìn)入我公司展臺(tái)查詢(xún)。

依魯替尼作用機(jī)理：依魯替尼是一種小分子BTK抑制劑，能夠與BTK活性中心的半胱氨酸殘基共價(jià)結(jié)合，從而抑制其活性。BTK全稱(chēng)Bruton'styrosinekinase，在BCR信號(hào)通路、細(xì)胞因子受體信號(hào)通路中傳遞信號(hào)，介導(dǎo)B細(xì)胞的遷移、趨化、粘附。臨床前研究證明，依魯替尼能夠抑制惡性B細(xì)胞的增殖、生存。臨床試驗(yàn)：111例既往至少接受過(guò)一項(xiàng)治療的患者經(jīng)依魯替尼治療后，總應(yīng)答率為65.8%（*應(yīng)答17.1%+部分應(yīng)答48.6%），中位持續(xù)應(yīng)答時(shí)間為17.5個(gè)月。

附：深圳遠(yuǎn)揚(yáng)化學(xué)提供依魯替尼雜質(zhì)庫(kù)存列表：

若列表中無(wú)您需要的雜質(zhì)，詳詢(xún)，我司可提供依魯替尼雜質(zhì)定制服務(wù)。

Ibrutinib	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Ibrutinib Impurity 1	(S)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Ibrutinib Impurity 2	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Ibrutinib Impurity 3	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one
Ibrutinib Impurity 4	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethanone
Ibrutinib Impurity 5	1,3-bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Ibrutinib Impurity 6	3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Ibrutinib Impurity 7	(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Ibrutinib Impurity 8	(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Ibrutinib Impurity 9	1-((R)-3-(4-((3-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)amino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Ibrutinib Impurity 10	(R)-N-(1-(1-acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)acrylamide

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依魯替尼雜質(zhì)長(zhǎng)期備有庫(kù)存

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