Cytokeratin 20(細胞角蛋白20)

廣州健侖生物科技有限公司

細胞角蛋白20（CK20）分子量為46KDa，主要研究胃腸道上皮、尿道上皮和Merkel 細胞。主要用于胃腸道腫瘤、泌尿道腫瘤、卵巢黏液性腫瘤和Merkel 細胞癌的研究。鱗癌、乳腺癌、肺癌、子宮內(nèi)膜癌和卵巢非黏液性腫瘤均不表達CK20。細胞角蛋白19片段（Cytokeratin-19-fragment CYFRA21-1)是肺泡上皮細胞凋亡時，其細胞中含有的角蛋白的碎片降解后變成可溶性物質而進入血液，使血中含量增高。非小細胞肺癌的*標志物。特別是鱗狀上皮細胞癌目前*的腫瘤標志物，靈敏度可達60%，特異性可達95%。它對非小細胞肺癌(NSCLC)的早期診斷、療效監(jiān)測和預后判斷均有重要意義。監(jiān)測非小細胞肺癌的病程和預后。血中CYFRA21-1水平顯著升高提示腫瘤的晚期或預后差；如果對非小細胞肺癌的治療效果好，其水平會很快下降或恢復到正常水平，如值不變或輕度減低提示腫瘤未*去除或有多發(fā)性腫塊存在。

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Cytokeratin 20(細胞角蛋白20)

【產(chǎn)品介紹】

細胞定位：細胞漿

克隆號：Ks20.8

同型：IgG2a/K

適用組織：石蠟/冰凍

陽性對照：直腸

抗原修復：熱修復（EDTA）

抗體孵育時間：30-60min

Cytokeratin 20(細胞角蛋白20)

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Cytokeratin 20 (CK20) has a molecular weight of 46 kDa and is mainly studied in the gastrointestinal epithelium, urothelium and Merkel cells. Mainly used for gastrointestinal tumors, urinary tract tumors, ovarian mucinous tumors and Merkel cell carcinoma research. CK20 was not expressed in squamous cell carcinoma, breast cancer, lung cancer, endometrial cancer and ovarian non-mucinous tumors. Cytokeratin 19 fragment (Cytokeratin-19-fragment CYFRA21-1) is alveolar epithelial cell apoptosis, the cells contained in the degradation of keratin fragments become soluble substances into the blood, so that blood levels. Preferred marker for non-small cell lung cancer. In particular squamous cell carcinoma is currently the preferred tumor marker, the sensitivity of up to 60%, the specificity of up to 95%. It is of great importance for the early diagnosis, curative effect monitoring and prognosis judgment of non-small cell lung cancer (NSCLC). Monitor the course and prognosis of non-small cell lung cancer. A significant increase in blood levels of CYFRA21-1 suggests a poor late or poor prognosis of the tumor; if the effect on non-small cell lung cancer is good, the level will rapidly decline or return to normal levels, as invariant or mild decrease in value suggests a tumor Not compley removed or there are multiple bumps.