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APC腺瘤性結(jié)腸息肉病蛋白

廣州健侖生物科技有限公司

結(jié)腸息肉指的是隆起于結(jié)腸黏膜表皮，向腔內(nèi)突起的贅生物。息肉的大小不等，多數(shù)結(jié)腸息肉患者早期臨床癥狀輕微或者沒有癥狀，往往是常規(guī)結(jié)腸鏡或者鋇灌腸檢查時(shí)偶然發(fā)現(xiàn)的。20世紀(jì)70年代以后，由于內(nèi)鏡、X線、B超等檢查技術(shù)的進(jìn)步，消化道息肉的發(fā)現(xiàn)率大大提高了。因?yàn)槠湟话銢]有臨床癥狀，臨床上只有很少一部分腸息肉患者出現(xiàn)便血、黏液便、腹痛等異常，而這些癥狀也常常缺乏特異性，因此要確診腸息肉還得依賴結(jié)腸鏡等器械檢查。

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【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿/細(xì)胞核

克隆號(hào)：polyclonal

同型：IgG1

適用組織：石蠟/冰凍

陽性對(duì)照：腺瘤

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：60min

APC腺瘤性結(jié)腸息肉病蛋白

并發(fā)癥
1.腸道并發(fā)癥
（1）腸穿孔 急性腸穿孔多發(fā)生于嚴(yán)重的阿米巴腸病患者，穿孔部位多見于盲腸、闌尾和升結(jié)腸。慢性穿孔先形成腸粘連，爾后常形成局部膿腫或穿入附近抗原抗體形成內(nèi)瘺。
（2）腸出血 發(fā)生率少于1%，一般可發(fā)生于阿米巴痢疾或肉芽腫患者，因潰瘍侵及腸壁血管所致。大量出血雖少見，但一旦發(fā)生，病情危急，常因出血而致休克。小量出血多由于淺表潰瘍滲血所致。
（3）闌尾炎 因阿米巴腸病好發(fā)于盲腸部位，故累及闌尾的機(jī)會(huì)較多。其癥狀與細(xì)菌性闌尾炎相似，亦有急慢性等表現(xiàn)。
（4）阿米巴瘤 腸壁產(chǎn)生大量肉芽組織，形成可觸及的腫塊。多發(fā)生在盲腸，亦見于橫結(jié)腸、直腸及抗原抗體，常伴疼痛，極似腫瘤，不易與腸癌區(qū)別。瘤體增大時(shí)可引起腸梗阻。
（5）腸腔狹窄 慢性患者，腸道潰瘍的纖維組織修復(fù)，可形成瘢痕性狹窄，并出現(xiàn)腹部絞痛、嘔吐、腹脹及梗阻癥狀。
（6）抗原抗體周圍阿米巴病 該病較少見，在臨床上常誤診。當(dāng)有皮膚損傷或肛裂、肛管炎及隱窩炎等病變時(shí)，阿米巴滋養(yǎng)體即可直接侵入皮膚內(nèi)而引起抗原抗體周圍阿米巴病，有時(shí)病變可繼發(fā)于掛線法治療痔瘺之后，阿米巴滋養(yǎng)體偶可通過血行感染抗原抗體周圍組織，出現(xiàn)粟粒樣大小棕色皮疹，其疹扁平隆起，邊緣不清，zui后形成潰瘍或膿腫，破裂后排出膿液及分泌物。易被誤診為直腸肛管癌、基底細(xì)胞癌或皮膚結(jié)核等。
2.腸外并發(fā)癥
阿米巴滋養(yǎng)體可自腸道抗原抗體流-淋巴蔓延遠(yuǎn)處抗原抗體而引起各種腸外并發(fā)癥，其中以肝膿腫為是常見，其次如肺、胸膜、心包、腦、腹膜、胃、膽囊、皮膚、泌尿系統(tǒng)、女性生殖系統(tǒng)等均可侵及。
治療
1.一般治療
急性期必須臥床休息，必要時(shí)給予輸液。根據(jù)病情給予流質(zhì)或半流質(zhì)飲食。慢性患者應(yīng)加強(qiáng)營養(yǎng)，以增強(qiáng)體質(zhì)。
2.病原治療
（1）甲硝咪唑（滅滴靈） 對(duì)阿米巴滋養(yǎng)體有較強(qiáng)的殺滅作用且較安全，適用于腸內(nèi)腸外各型的阿米巴病，為目前抗阿米巴病的*藥物。
（2）甲硝磺酰咪唑 是硝基咪唑類化合物的衍生物。療效與滅滴相似或更佳。
（3）抗原抗體 對(duì)組織內(nèi)滋養(yǎng)體有有高的殺滅作用，但對(duì)腸腔內(nèi)阿米巴無效。本藥控制急性癥狀極有效，但*率低，需要與鹵化喹啉類藥物等合量用藥。本藥毒性較大，幼兒、孕婦，有心血管及腎臟病者禁用。如需重復(fù)治療，至少隔6周。
（4）鹵化喹啉類 主要作用于腸腔內(nèi)而不是組織內(nèi)阿米巴滋養(yǎng)體。對(duì)輕型、排包囊者有效，對(duì)重型或慢性患者常與抗原抗體或滅滴靈聯(lián)合應(yīng)用。
（5）其他 安特酰胺、巴龍霉素、安痢平，以上3藥都作用于腸腔內(nèi)阿米巴。
（6）中草藥 鴉膽子，大蒜，白頭翁。
以上各種藥物除滅滴靈外，往往需要2種或2種以上藥物的聯(lián)合應(yīng)用，方能獲得較好效果。

我司還提供其它進(jìn)口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

complication
1. Intestinal complications
(1) intestinal perforation of acute intestinal perforation occurred in patients with severe amoebic enteropathy, perforated site more common in the cecum, appendix and ascending colon. Chronic perforation to form intestinal adhesions, often after the formation of local abscess or penetrate the vicinity of the antigen-forming fistula.
(2) The incidence of intestinal bleeding less than 1%, generally occurs in patients with amoebic dysentery or granuloma, due to invasion of ulcers and intestinal vascular. Although a large number of bleeding is rare, but in the event of a critical condition, often because of bleeding and shock. A small amount of bleeding due to superficial ulcer bleeding.
(3) appendicitis due to amoebic bowel disease occurs in the cecum, it is more likely to involve the appendix. Symptoms and bacterial appendicitis similar, but also acute and chronic manifestations.
(4) Ameba tumor wall produces a large number of granulation tissue, forming palpable mass. Occurred in the cecum, also found in the transverse colon, rectum and antigen antibodies, often accompanied by pain, like a tumor, not easy to distinguish with the colon cancer. Tumor can cause intestinal obstruction when increased.
(5) chronic intestinal stenosis, intestinal ulcer fibrous tissue repair, the formation of cicatricial stenosis, and abdominal cramps, vomiting, abdominal distension and obstruction symptoms.
(6) Antibodies Antibodies around the amoebiasis The disease is rare, clinically misdiagnosed. When skin lesions or anal fissure, anal inflammation and cryptitis and other lesions, amebic trophozoites can directly invade the skin and cause antigen-antibody around the amoebiasis, and sometimes lesions can be secondary to hanging line therapy After hemorrhoids fistulae, the amoeba trophozoites can infect peripheral tissues of the antigen and antibody through the bloodstream, and a miliary-like brown rash appears. The rash is flattened and the margin is unclear. Finally, ulcers or abscesses are formed, and the pus and secretions are discharged after the rupture. Easily misdiagnosed as rectal anal cancer, basal cell carcinoma or skin tuberculosis.
2. Parenteral complications
Amoeba trophozoites can cause various parenteral complications from the antigen-antibody of intestinal antigen-antibody-lymphatic spread at distant places, among them liver abscess is common, followed by lung, pleura, pericardium, brain, peritoneum, Gallbladder, skin, urinary system, female reproductive system, etc. can be invading.
treatment
1. General treatment
Acute phase must be bed rest, if necessary, give infusion. According to the condition to give liquid or semi-liquid diet. Chronic patients should strengthen nutrition, to enhance physical fitness.
Pathogen treatment
(1) metronidazole (metronidazole) on the amoeba trophozoites have a strong killing effect and more secure, suitable for various types of enterocolitis amebiasis, for the current anti-amoebiasis Preferred drug.
(2) Methylsulfonyl imidazole is a derivative of nitroimidazole. Efficacy and off-drip similar or better.
(3) Antigen Antibody has a high killing effect on trophozoites in the tissue, but is not effective on enteric amoeba. The acute symptoms of the drug control very effective, but the cure rate is low, the need to use halogenated quinoline drugs and so on. The drug toxicity, children, pregnant women, cardiovascular and kidney disease disabled. For repeated treatment, at least every 6 weeks.
(4) Haloquinolines mainly act on the intestine rather than the tissue amebic trophozoites. For light, row cysts effective, often in patients with severe or chronic antigen or metronidazole combined use.
(5) other Anteamide, paromomycin, safety dysentery, the above three drugs are used in the intestinal lumen amoeba.
(6) Chinese herbal javanica, garlic, Pulsatilla.
In addition to all the above drugs in addition to metronidazole, often require two or more than two drugs in combination, in order to obtain better results.