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上海允麥生物科技有限公司
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Recombinant human VSIG4 protein
V-set and immunoglobulin domain-containing protein 4; CRIg; V set and immunoglobulin domain containing 4; Z39IG; VSIG4_HUMAN.
濃度：1mg/ ml
來(lái)源：Recombinant Human
純度：≥95% SDS-PAGE
表達(dá)系統(tǒng)：HEK 293 cells
標(biāo)簽：His tag C-Terminus
蛋白長(zhǎng)度：Full length protein
內(nèi)毒素水平：<1.000 Eu/µg
純化方法：HPLC
應(yīng)用：SDS-PAGE，Western blot，ELISA
Biological activity,immunology research
保存：-20℃
保質(zhì)期：1年
T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 familyrelated protein V-set and Ig domaincontaining 4 (VSIG4). Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th celldependent IgG responses. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.
產(chǎn)品名稱：Rabbit Anti-VSIG4 protein antibody
Rabbit Anti-VSIG4 protein
別名：V-set and immunoglobulin domain-containing protein 4; CRIg; V set and immunoglobulin domain containing 4; Z39IG; VSIG4_HUMAN.
來(lái)源：Rabbit
克隆類型：Polyclonal
濃度：1mg/ml
亞型：IgG
反應(yīng)：Mouse,Rat (predicted: Human,Cow,Dog)
應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500
IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
理論分子量：33kDa
免疫原：KLH conjugated synthetic peptide derived from human VSIG4 protein
保存：-20℃
保質(zhì)期：1年
產(chǎn)品名稱：Anti-VSIG4 protein antibody
Mouse Anti-VSIG4 protein
別名：V-set and immunoglobulin domain-containing protein 4; CRIg; V set and immunoglobulin domain containing 4; Z39IG; VSIG4_HUMAN.
來(lái)源：Mouse
克隆類型：Monoclonal
濃度：1mg/ml
亞型：IgG
反應(yīng)：Human
應(yīng)用：WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500
IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
反應(yīng): Human
理論分子量：33kDa
免疫原：KLH conjugated synthetic peptide derived from human VSIG4
保存：-20℃
保質(zhì)期：1年
T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 familyrelated protein V-set and Ig domaincontaining 4 (VSIG4). Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th celldependent IgG responses. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.
