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上海允麥生物科技有限公司
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Recombinant human UVRAG
DHTX; Disrupted in heterotaxy; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated gene protein; UV radiation resistance-associated gene protein; UVRAG; UVRAG_HUMAN.
濃度：1mg/ ml
來(lái)源：Recombinant Human
純度：≥90% SDS-PAGE
表達(dá)系統(tǒng)：Escherichia coli
標(biāo)簽：His tag
蛋白長(zhǎng)度：Full length protein
內(nèi)毒素水平：<1.000 Eu/µg
純化方法：HPLC
應(yīng)用：SDS-PAGE，Western blot，ELISA
Biological activity,immunology research
保存：-20℃
保質(zhì)期：1年
UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.
抗體
產(chǎn)品名稱：Rabbit Anti-UVRAG antibody
Rabbit Anti-UVRAG
別名：DHTX; Disrupted in heterotaxy; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated gene protein; UV radiation resistance-associated gene protein; UVRAG; UVRAG_HUMAN.
來(lái)源：Rabbit
克隆類型：Polyclonal
濃度：1mg/ml
亞型：IgG
應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
反應(yīng)：Human,Mouse,Rat,Dog,Horse
理論分子量：78kDa
免疫原：KLH conjugated synthetic peptide derived from Human UVRAG
保存：-20℃
保質(zhì)期：1年
單克隆抗體
產(chǎn)品名稱：Anti-UVRAG antibody
Mouse Anti-UVRAG
別名：DHTX; Disrupted in heterotaxy; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated gene protein; UV radiation resistance-associated gene protein; UVRAG; UVRAG_HUMAN.
來(lái)源：Mouse
克隆類型：Monoclonal
濃度：1mg/ml
亞型：IgG
應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
反應(yīng): Human
理論分子量：78kDa
免疫原：KLH conjugated synthetic peptide derived from Human UVRAG
保存：-20℃
保質(zhì)期：1年
UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.
