The PRMT1 Homogeneous Assay Kit is designed to measure PRMT1 activity for screening and profiling applications. PRMT1 is a histone methyltransferase that exhibits methylation activity toward H4-R3. The key to the PRMT1 Homogeneous Assay Kit is a highly specific antibody that recognizes methylated histone substrate. With this kit, only three simple steps on a microtiter plate are required for methyltransferase detection. First, a sample containing PRMT1 enzyme is incubated with the biotinylated substrate for one hour. Next, acceptor beads and primary antibody are added, then donor beads, followed by reading the Alphacounts.

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