MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

KDM5-IN-1

CAS No. : 1628210-26-3

產(chǎn)品活性：KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC₅₀ of 15.1 nM.

研究領(lǐng)域：Epigenetics

作用靶點：Histone Demethylase

In Vitro: KDM5-IN-1 is found to potently inhibit KDM5B and KDM5C isoforms (IC₅₀ of 4.7 and 65.5 nM, respectively). It is significantly less potent against other KDM enzymes (1A, 2B, 3B, 4C, 5A, 6A, 7B), inhibiting KDM4C the strongest with an IC₅₀ of 1.9 μM. KDM5-IN-1 still displays more than 100-fold selectivity for KDM4C vs. KDM5A.

In Vivo: When dosed orally in mice at 50 mg/kg twice a day, KDM5-IN-1 shows an unbound maximal plasma concentration C_max>15-fold over its cell EC₅₀, thereby providing a robust chemical probe for studying KDM5 biological functions in vivo.

相關(guān)產(chǎn)品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Orally Active Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Targeted Diversity Library  |  Heterocyclic Compound Library  |  GSK2879552 dihydrochloride  |  KDM2B-IN-3  |  KDM4-IN-2  |  LSD1/ER-IN-1  |  GSK-J4 hydrochloride  |  Bomedemstat hydrochloride  |  LSD1-IN-18  |  KDM4-IN-4  |  (1S,2R)-Tranylcypromine hydrochloride  |  Pulrodemstat benzenesulfonate  |  GSK-J1 lithium salt  |  CPI-4203  |  JQKD82  |  Corin  |  Tranylcypromine hemisulfate  |  KDM2B-IN-4  |  LSD1-IN-14  |  Helenalin acetate  |  KDM2B-IN-2  |  Seclidemstat  |  GSK-LSD1 dihydrochloride  |  LSD1-IN-21  |  KDM4-IN-3  |  LSD1/2-IN-4  |  NCDM-32B  |  Eicosapentaenoic Acid  |  LSD1-IN-15

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領(lǐng)；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā)、生命科學(xué)等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學(xué)分析檢測分析，藥物篩選等專業(yè)技術(shù)服務(wù)；
•   設(shè)有專業(yè)的實驗中心和嚴(yán)格的質(zhì)控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質(zhì)檢報告，確保產(chǎn)品的高純度、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團(tuán)隊跟蹤新的制藥及生命科學(xué)研究進(jìn)展，為您提供*新的活性化合物；
•   與世界各大制藥公司及*科研機構(gòu)建立了長期的合作。