国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

產品推薦:氣相|液相|光譜|質譜|電化學|元素分析|水分測定儀|樣品前處理|試驗機|培養(yǎng)箱


化工儀器網(wǎng)>技術中心>其他文章>正文

歡迎聯(lián)系我

有什么可以幫您? 在線咨詢

測量應用案例-2016-66

來源:美國布魯克海文儀器公司   2016年10月26日 11:05  

文獻名: Polymeric micellar nanoplatforms for Fenton reaction as a new class of antibacterial agents

 

作者 Seong-Cheol Parka, Nam-Hong Kima, Wonseok Yangb, Jae-Woon Naha, Mi-Kyeong Janga, Dongwon Leeb, c,

a Department of Polymer Science and Engineering, Sunchon National University, 255 Jungang-ro, Suncheon, Chonnam, 540-950, Republic of Korea

b Department of BIN Convergence Technology, 567 Baekje-daero, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea

c Department of PolymerNano Science and Technology, 567 Baekje-daero, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea

 

摘要:Reactive oxygen species (ROS) produced by host phagocytes exert antibacterial action against a variety of pathogens and ROS-induced oxidative stress is the governing mechanism for the antibacterial activity of major bactericidal antibiotics. In particular, hydroxyl radical is a strong and nonselective oxidant which can damage biomolecules such as DNA, proteins and lipids. Ferrous ion is known to convert mild oxidant hydrogen peroxide (H2O2) into highly reactive and toxic hydroxyl radicals, referred to as Fenton reaction. Herein, we report a new class of antibacterial agents based on Fenton reaction-performing nanostructures, composed of H2O2-generating polymer (PCAE) and iron-containing ferrocene. Amphiphilic PCAE was designed to incorporate H2O2-generating cinnamaldehyde through acid-cleavable linkages and self-assemble to form thermodynamically stable micelles which could encapsulate ferrocene in their hydrophobic core. All the experiments in vitro display that ferrocene-loaded PCAE micelles produce hydroxyl radicals to kill Escherichia coli and Pseudomonas aeruginosa through membrane damages. Intraperitoneally injected ferrocene-loaded PCAE micelles significantly reduced the lung damages and therefore increased the survival rate of mice infected with drug resistant P. aeruginosa. Given their potent antibacterial activity, ferrocene-loaded PCAE micelles hold great potential as a new class of ROS-manipulating antibacterial agents.

免責聲明

  • 凡本網(wǎng)注明“來源:化工儀器網(wǎng)”的所有作品,均為浙江興旺寶明通網(wǎng)絡有限公司-化工儀器網(wǎng)合法擁有版權或有權使用的作品,未經本網(wǎng)授權不得轉載、摘編或利用其它方式使用上述作品。已經本網(wǎng)授權使用作品的,應在授權范圍內使用,并注明“來源:化工儀器網(wǎng)”。違反上述聲明者,本網(wǎng)將追究其相關法律責任。
  • 本網(wǎng)轉載并注明自其他來源(非化工儀器網(wǎng))的作品,目的在于傳遞更多信息,并不代表本網(wǎng)贊同其觀點和對其真實性負責,不承擔此類作品侵權行為的直接責任及連帶責任。其他媒體、網(wǎng)站或個人從本網(wǎng)轉載時,必須保留本網(wǎng)注明的作品第一來源,并自負版權等法律責任。
  • 如涉及作品內容、版權等問題,請在作品發(fā)表之日起一周內與本網(wǎng)聯(lián)系,否則視為放棄相關權利。
企業(yè)未開通此功能
詳詢客服 : 0571-87858618
苏尼特右旗| 包头市| 永德县| 武汉市| 彰化县| 土默特右旗| 始兴县| 象山县| 合作市| 宣恩县| 张掖市| 怀化市| 威信县| 榆树市| 淅川县| 遵化市| 米易县| 应用必备| 潼关县| 新和县| 霍林郭勒市| 瑞金市| 息烽县| 大姚县| 永宁县| 新闻| 措美县| 盐池县| 雷山县| 香格里拉县| 丰都县| 广水市| 东宁县| 班戈县| 乐清市| 龙川县| 商都县| 广水市| 湘西| 通化县| 商城县|