国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

產(chǎn)品推薦:氣相|液相|光譜|質(zhì)譜|電化學|元素分析|水分測定儀|樣品前處理|試驗機|培養(yǎng)箱


化工儀器網(wǎng)>技術(shù)中心>技術(shù)參數(shù)>正文

歡迎聯(lián)系我

有什么可以幫您? 在線咨詢

測量應用案例-2016-88

來源:美國布魯克海文儀器公司   2016年12月30日 13:47  
 文獻名: Delivery of HDAC1 siRNA by Mn-Doped ZnSe Quantum Dots to Induce Human Mesenchymal Stem Cells Differentiation Into Cardiomyocytes

 

作者 Li, Lin; Dong, Feng; Yang, Cheng-Jian; Ye, Xin-He; Xu, Xin; Cao, Jia-Ning

 

 

摘要:Cell-based therapies for cardiac repair have great promise for cardiovascular disease. The ability of human stem cells to differentiate into cardiomyocytes has attracted great attention in tissue engineering and other biochemical fields. In this study, we developed Poly-allylamine hydrochloride (PAH) coated Mn-doped ZnSe quantum dots (Mn:ZnSe QDs) as gene nanocarriers to deliver small interfering RNA (siRNA) against Histone deacetylase 1 (HDAC1) in human mesenchymal stem cells (human MSCs). Under the treatment of 5-azacytidine, the ablation of HDAC1 could significantly promote the differentiation of MSCs into cardiomyocytes in vitro. To further study the mechanism, we tested the stemness and differentiation genes and found that these genes had been changed by the down-regulation of HDAC1 in human MSCs. It is worth noting that Mn:ZnSe QDs can not only be served as the siRNA delivery platform, but the fluorescence from Mn:ZnSe QDs can also be applied as probes for tracking siRNA or chemotherapeutic drugs in cells or tissues. In conclusion, our results suggest for the first time use of Mn:ZnSe QDs as nanocarriers of delivery HDAC1 siRNA to induce the differentiation of human MSCs into cardiomyocytes for cardiovascular therapy, which may be clinically used to treat cardiovascular disease.

免責聲明

  • 凡本網(wǎng)注明“來源:化工儀器網(wǎng)”的所有作品,均為浙江興旺寶明通網(wǎng)絡有限公司-化工儀器網(wǎng)合法擁有版權(quán)或有權(quán)使用的作品,未經(jīng)本網(wǎng)授權(quán)不得轉(zhuǎn)載、摘編或利用其它方式使用上述作品。已經(jīng)本網(wǎng)授權(quán)使用作品的,應在授權(quán)范圍內(nèi)使用,并注明“來源:化工儀器網(wǎng)”。違反上述聲明者,本網(wǎng)將追究其相關(guān)法律責任。
  • 本網(wǎng)轉(zhuǎn)載并注明自其他來源(非化工儀器網(wǎng))的作品,目的在于傳遞更多信息,并不代表本網(wǎng)贊同其觀點和對其真實性負責,不承擔此類作品侵權(quán)行為的直接責任及連帶責任。其他媒體、網(wǎng)站或個人從本網(wǎng)轉(zhuǎn)載時,必須保留本網(wǎng)注明的作品第一來源,并自負版權(quán)等法律責任。
  • 如涉及作品內(nèi)容、版權(quán)等問題,請在作品發(fā)表之日起一周內(nèi)與本網(wǎng)聯(lián)系,否則視為放棄相關(guān)權(quán)利。
企業(yè)未開通此功能
詳詢客服 : 0571-87858618
甘孜| 汉沽区| 咸阳市| 柳林县| 来宾市| 昔阳县| 水富县| 尚志市| 前郭尔| 襄城县| 阿图什市| 华池县| 兰西县| 卓尼县| 庆元县| 饶平县| 夏河县| 拉萨市| 克拉玛依市| 邵阳县| 会宁县| 左权县| 枝江市| 祁东县| 寻乌县| 徐州市| 井陉县| 洛南县| 马关县| 宜州市| 天台县| 建平县| 噶尔县| 惠安县| 清苑县| 十堰市| 陇南市| 慈溪市| 凤凰县| 娄烦县| 普兰店市|