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非布司他雜質(zhì) 非布索坦雜質(zhì)申報(bào)
非布司他適應(yīng)癥及作用機(jī)理：非布司他主要成份為非布佐司他，其化學(xué)名為2-[(3-氰基-4-異丁氧基)苯基]-4-甲基-5-噻唑羧酸。為黃嘌呤氧化酶（XO）抑制劑，適用于具有痛風(fēng)癥狀的高尿酸血癥的長期治療。非布佐司他是黃嘌呤氧化酶抑制劑，通過減少血清尿酸達(dá)到療效。本品在治療濃度下不會(huì)抑制嘌呤和嘧啶的合成及代謝過程中的其他酶。
深圳遠(yuǎn)揚(yáng)化學(xué)技術(shù)有限公司提供的非布司他雜質(zhì)純度高，來源正規(guī)，*非布司他新藥申報(bào)的要求，隨貨提供COA證書，氫譜，質(zhì)譜及HPLC，。（請(qǐng)點(diǎn)擊本頁標(biāo)題下方“進(jìn)入該公司展臺(tái)” 查看我司信息）。
| Febuxostat | 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 1 | ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 2 | ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 3 | ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 4 | 2-(3-carbamoyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 5 | ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 6 | (E)-ethyl 2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 7 | (E)-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 8 | 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 9 | 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 10 | 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid 1-oxide |
| Febuxostat Impurity 11 | 2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 12 | 4-isobutoxybenzene-1,3-bis(carbothioamide) |
| Febuxostat Impurity 13 | dimethyl 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylate) |
| Febuxostat Impurity 14 | 2-isobutoxy-5-(4-methylthiazol-2-yl)benzonitrile |
| Febuxostat Impurity 15 | 2-(4-butoxy-3-cyanophenyl)thiazole-5-carboxylic acid |
| Febuxostat Impurity 16 | 2-(4-(sec-butoxy)-3-cyanophenyl)thiazole-5-carboxylic acid |
| Febuxostat Impurity 17 | 2-(3-cyano-4-propoxyphenyl)thiazole-5-carboxylic acid |
| Febuxostat Impurity 18 | ethyl 2-(4-hydroxy-3-vinylphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 19 | ethyl 2-(2-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 20 | 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylic acid) |
| Febuxostat Impurity 21 | diethyl 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylate) |
| Febuxostat Impurity 22 | ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 23 | 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 24 | 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 25 | 2-(3-carboxy-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 26 | 2-(3-carbamoyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 27 | 2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 28 | 2-(4-(sec-butoxy)-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 29 | 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 30 | 2-(3-cyano-4-ethoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 31 | (E)-ethyl 2-(4-hydroxy-3-((hydroxyimino)methyl)phenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 32 | ethyl 2-(3-formyl-2-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 33 | 2-(3-cyano-4-isopropoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 34 | isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 35 | methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 36 | 2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid |
| Febuxostat Impurity 37 | ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Febuxostat Impurity 38 | 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid |
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