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MRI-visible liposome–polyethylenimine complexes for DNA delivery: preparation and evaluation

來(lái)源:美國(guó)布魯克海文儀器公司   2019年05月27日 15:04  
 作者: Xiaowei Song1, Guanghai Yan1, Songshi Quan1, Enhao Jin1, Jishan Quan2 & Guangyu Jin1

1Department of Radiology, Yanbian University Hospital, Yanji, China

2College of Pharmacy, Yanbian University, Yanji, China

 

摘要:To noninvasively monitor the effect of gene therapy and achieve an optimal therapeutic effect, liposomes encapsulated polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles (SPION) with dual functions of MRI diagnosis and gene therapy were prepared. SPION was synthesized via co-precipitation, and then modified with PEI via thiourea reaction. The liposomes encapsulating PEI-SPION (LP-PEI-SPION) were prepared by ethanol injection. Fourier transform infrared spectra confirmed that PEI was successfully modified onto SPION, and thermogravimetric analysis indicated that the PEI content was about 17.1%. The LP-PEI-SPION/DNA had a small particle size of 253.07 ± 0.90 nm. LP-PEI-SPION/DNA had low cytotoxicity with more than 80% of the cell survival rates and high transfection efficiency compared with Lipofectamine® 2000/DNA. Additionally, it also showed good MRI effect on three cell lines. The liposomes encapsulating PEI-SPION (lipopolyplexes) have been successfully prepared as MRI contrast agents and gene delivery vectors, which may have great theoretical research significance and clinical potentials.

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