国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

產(chǎn)品推薦:氣相|液相|光譜|質(zhì)譜|電化學(xué)|元素分析|水分測定儀|樣品前處理|試驗機|培養(yǎng)箱


化工儀器網(wǎng)>技術(shù)中心>其他文章>正文

歡迎聯(lián)系我

有什么可以幫您? 在線咨詢

測量應(yīng)用案例-20190710

來源:美國布魯克海文儀器公司   2019年07月22日 13:49  

文獻(xiàn)名: Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment

 

作者: Khoi Nguyen*, Hsuan-Yeh Pan, Kevin Haworth*†, Eric Mahoney*, Karla P. Mercado-Shekhar, Chia-Ying Lin, Zhe Zhang§, Yoonjee C. Park

*Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA

Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA

Department of Orthopaedic Surgery, University of Cincinnati, Cincinnati, Ohio, USA

§Department of Chemical & Environmental Engineering, University of Cincinnati, Cincinnati, Ohio, USA

 

摘要:The combination of simvastatin and CF680 dye encapsulated by stable nanodroplets has been developed as a drug delivery carrier. Simvastatin has previously been found to be a potential degenerative disc disease treatment. Multiple exposures of the nanodroplets to high-intensity focused ultrasound induced release of simvastatin. Each ultrasound exposure yielded a consistent concentration of the drug and dye released. B-mode ultrasound image analysis data and cavitation data clearly indicated the release mechanism is phase transition of the liquid nanodroplets into gas bubbles. The nanodroplets were stably stored in ex vivo rabbit spinal discs for at least 14 days, and the contents responded to ultrasound exposure on demand. Lastly, nucleus pulposus cells harvested from rabbit spine discs and exposed to media with nanodroplets exhibited a decrease in cell viability (85%) relative to the cells only (96.7%) at 24 h, but no difference at 48 h. Thus, the system may be a potential degenerative disc disease treatment.

免責(zé)聲明

  • 凡本網(wǎng)注明“來源:化工儀器網(wǎng)”的所有作品,均為浙江興旺寶明通網(wǎng)絡(luò)有限公司-化工儀器網(wǎng)合法擁有版權(quán)或有權(quán)使用的作品,未經(jīng)本網(wǎng)授權(quán)不得轉(zhuǎn)載、摘編或利用其它方式使用上述作品。已經(jīng)本網(wǎng)授權(quán)使用作品的,應(yīng)在授權(quán)范圍內(nèi)使用,并注明“來源:化工儀器網(wǎng)”。違反上述聲明者,本網(wǎng)將追究其相關(guān)法律責(zé)任。
  • 本網(wǎng)轉(zhuǎn)載并注明自其他來源(非化工儀器網(wǎng))的作品,目的在于傳遞更多信息,并不代表本網(wǎng)贊同其觀點和對其真實性負(fù)責(zé),不承擔(dān)此類作品侵權(quán)行為的直接責(zé)任及連帶責(zé)任。其他媒體、網(wǎng)站或個人從本網(wǎng)轉(zhuǎn)載時,必須保留本網(wǎng)注明的作品第一來源,并自負(fù)版權(quán)等法律責(zé)任。
  • 如涉及作品內(nèi)容、版權(quán)等問題,請在作品發(fā)表之日起一周內(nèi)與本網(wǎng)聯(lián)系,否則視為放棄相關(guān)權(quán)利。
企業(yè)未開通此功能
詳詢客服 : 0571-87858618
岑巩县| 塘沽区| 南皮县| 仁怀市| 西畴县| 福清市| 绍兴县| 怀柔区| 福泉市| 京山县| 扶余县| 古交市| 南召县| 平武县| 景泰县| 马边| 舒兰市| 永丰县| 唐河县| 威海市| 来宾市| 九龙坡区| 马尔康县| 怀来县| 邵武市| 白山市| 巴里| 汤阴县| 高青县| 太保市| 和田县| 玉门市| 青岛市| 手机| 保康县| 都昌县| 韩城市| 托克托县| 徐闻县| 正蓝旗| 泸西县|