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產(chǎn)品介紹
BioXcell InVivoPlus anti-mouse Ly6G 1A8單克隆抗體與小鼠Ly6G反應。Ly6G分子量為21-25kDa，是GPI錨定的細胞表面蛋白Ly-6超家族的成員，在細胞信號傳導和細胞粘附中發(fā)揮作用。Ly6G在發(fā)育過程中由骨髓譜系中的細胞（包括單核細胞、巨噬細胞、粒細胞和嗜中性粒細胞）差異表達。單核細胞通常在發(fā)育過程中瞬時表達Ly6G，而成熟的粒細胞和外周嗜中性粒細胞保持表達，使Ly6G成為這些群體的良好細胞表面標志物。與BioXcell RB6-8C5抗體不同，1A8抗體與小鼠Ly6G特異性反應，而與Ly6C沒有交叉反應性的報道。
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產(chǎn)品詳情
產(chǎn)品名稱 | InVivoPlus anti-mouse Ly6G |
產(chǎn)品貨號 | BP0075-1 |
產(chǎn)品規(guī)格 | 5/25/50/100mg |
反應種屬 | Mouse |
克隆號 | 1A8 |
同種型 | Rat IgG2a, κ |
免疫原 | EL4J cells transfected with Ly6G |
實驗應用 | in vivo neutrophil depletion in vivo MDSC depletion Immunofluorescence Immunohistochemistry (paraffin) Immunohistochemistry (frozen) Flow cytometry |
產(chǎn)品形式 | PBS, pH 7.0,Contains no stabilizers or preservatives |
純度 | >95%, Determined by SDS-PAGE |
聚合 | <5%, Determined by SEC |
無菌處理 | 0.2 µm filtration |
純化方式 | Protein G |
RRID | AB_1107721 |
分子量 | 150 kDa |
小鼠病原檢測 | Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
保存條件 | 抗體原液保存在4°C，不能冷凍保存。 |
推薦同型對照 | InVivoPlus rat IgG2a isotype control, anti-trinitrophenol（貨號BP0089） |
推薦抗體稀釋液 | InVivoPure pH 7.0 Dilution Buffer（貨號IP0070） |
為什么選擇InVivoPlus抗體？
InVivoPlus級別的產(chǎn)品內(nèi)毒素含量更低，經(jīng)過多種實驗驗證，更適合用于體內(nèi)實驗研究
該產(chǎn)品自上市已被多篇SCI文獻引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻引用：
應用 | 文章 |
體內(nèi)中性粒細胞耗竭 (in vivo neutrophil depletion) | 1. Davis, R. W. t., et al. (2018). 'Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy' Photochem Photobiol . 2. Moynihan, K. D., et al. (2016). 'Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses' Nat Med. doi : 10.1038/nm.4200. 3. Conde, P., et al. (2015). 'DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance' Immunity 42(6): 1143-1158. 4. Griseri, T., et al. (2015). 'Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis' Immunity 43(1): 187-199. 5. Yamada, D. H., et al. (2015). 'Suppression of Fcgamma-receptor-mediated antibody effector function during persistent viral infection' Immunity 42(2): 379-390. 6. Ellis, G. T., et al. (2015). 'TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection' EMBO Rep 16(9): 1203-1218. 7. Deshmukh, H. S., et al. (2014). 'The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice' Nat Med 20(5): 524-530. |
體內(nèi)中性粒細胞耗竭、流式細胞術(shù)、免疫組化石蠟切片(in vivo neutrophil depletion, Flow Cytometry, Immunohistochemistry (paraffin)) | Coffelt, S. B., et al. (2015). 'IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis' Nature 522(7556): 345-348. |
體內(nèi)中性粒細胞耗竭、流式細胞術(shù)、免疫組化石蠟切片、免疫組化冰凍切片(in vivo neutrophil depletion, Flow Cytometry, Immunohistochemistry (paraffin), Immunohistochemistry (frozen)) | Finisguerra, V., et al. (2015). 'MET is required for the recruitment of anti-tumoural neutrophils' Nature 522(7556): 349-353. |
體內(nèi)中性粒細胞耗竭、流式細胞術(shù)(in vivo neutrophil depletion, Flow Cytometry) | 1.Moser, E. K., et al. (2014). 'Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner' PLoS Pathog 10(8): e1004315. 2. Chen, K. W., et al. (2014). 'The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge' Cell Rep 8(2): 570-582. 3. Garraud, K., et al. (2012). 'Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax' Infect Immun 80(1): 131-142. 4. Lee, W. B., et al. (2012). 'Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway' PLoS Pathog 8(4): e1002614. |
體內(nèi)骨髓來源抑制細胞耗竭(in vivo MDSC depletion) | Deng, L., et al. (2014). 'Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice' J Clin Invest 124(2): 687-695. |
體內(nèi)中性粒細胞耗竭、免疫熒光(in vivo neutrophil depletion,Immunofluorescence) | Edelson, B. T., et al. (2011). 'CD8alpha(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes' Immunity 35(2): 236-248. |
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