国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

產品推薦:氣相|液相|光譜|質譜|電化學|元素分析|水分測定儀|樣品前處理|試驗機|培養(yǎng)箱


化工儀器網>技術中心>其他文章>正文

歡迎聯(lián)系我

有什么可以幫您? 在線咨詢

納米粒度測量應用案例-53-90Plus

來源:美國布魯克海文儀器公司   2015年07月20日 15:02  
 文獻名: Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate
 
作者: Ying Tu, Lin Zhu
Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University Health Science Center, Kingsville, TX 78363, United States
 
摘要:Undesirable physicochemical properties, low tumor targeting, insufficient cell internalization, acquired drug resistance, and severe side effects significantly limit the applications of anticancer drugs. In this study, to improve the tumor targeting and drug efficacy of the poorly water-soluble drug, doxorubicin (DOX), a novel drug delivery platform (PEG-ppTAT-DOX) was developed, which contained a polyethylene glycol (PEG), a matrix metalloproteinase 2 (MMP2)-sensitive peptide linker (pp), a cell penetrating peptide (TAT), and a model drug (doxorubicin). The prepared drug platform possessed several key features, including: (i) the nanoparticle formation via the self-assembly; (ii) prevention of the non-specific interaction via the PEGylation; (iii) tumor targeting via the MMP2-mediated PEG deshielding and exposure of the TAT; (iv) the TAT-mediated cell internalization; (v) the TAT-induced endosomal escape; (vi) the inhibition of P-glycoprotein mediated drug efflux; and (vii) the TAT-medicated nuclear translocation. These cooperative functions ensured the improved tumor targetability, enhanced tumor cell internalization, improved intracellular distribution, and potentiated anticancer activity. Compared to the multi-component nanocarriers, the proposed simple but multifunctional polymer-drug conjugate might have greater potential for tumor-targeted drug delivery and enhanced chemotherapy.
 
關鍵詞:Drug delivery; Tumor targeting; Multifunctional; Matrix metalloproteinase 2; Cell penetrating peptide; Polymer-drug conjugate
 

免責聲明

  • 凡本網注明“來源:化工儀器網”的所有作品,均為浙江興旺寶明通網絡有限公司-化工儀器網合法擁有版權或有權使用的作品,未經本網授權不得轉載、摘編或利用其它方式使用上述作品。已經本網授權使用作品的,應在授權范圍內使用,并注明“來源:化工儀器網”。違反上述聲明者,本網將追究其相關法律責任。
  • 本網轉載并注明自其他來源(非化工儀器網)的作品,目的在于傳遞更多信息,并不代表本網贊同其觀點和對其真實性負責,不承擔此類作品侵權行為的直接責任及連帶責任。其他媒體、網站或個人從本網轉載時,必須保留本網注明的作品第一來源,并自負版權等法律責任。
  • 如涉及作品內容、版權等問題,請在作品發(fā)表之日起一周內與本網聯(lián)系,否則視為放棄相關權利。
企業(yè)未開通此功能
詳詢客服 : 0571-87858618
南华县| 武宁县| 荣昌县| 武定县| 柏乡县| 乳源| 清涧县| 阳曲县| 宁强县| 黄石市| 石城县| 磐石市| 吉木乃县| 阜城县| 亚东县| 教育| 邛崃市| 邵东县| 屏山县| 故城县| 来安县| 襄樊市| 蓬溪县| 玉林市| 乌兰县| 宁晋县| 吴桥县| 天长市| 嫩江县| 兰溪市| 崇明县| 马鞍山市| 监利县| 白山市| 天津市| 元朗区| 秦安县| 忻城县| 平原县| 辽阳县| 温宿县|