国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

產(chǎn)品推薦:氣相|液相|光譜|質(zhì)譜|電化學(xué)|元素分析|水分測定儀|樣品前處理|試驗機|培養(yǎng)箱


化工儀器網(wǎng)>技術(shù)中心>其他文章>正文

歡迎聯(lián)系我

有什么可以幫您? 在線咨詢

Omni測量應(yīng)用案例-2016-21

來源:美國布魯克海文儀器公司   2016年06月20日 16:36  

文獻名: Chlorin e6 keratin nanoparticles for photodynamic anticancer therapy

 

作者 A. Aluigi,a   G. Sotgiu,a   C. Ferroni,a   S. Duchi,b   E. Lucarelli,b   C. Martini,a   T. Posati,a   A. Guerrini,a   M. Ballestri,a   F. Corticellic and    G. Varchia  

a Institute of Organic Synthesis and Photoreactivity – Italian National Research Council, Via Gobetti 101, 40129 Bologna, Italy

b Osteoarticular Regeneration Laboratory, Rizzoli Orthopaedic Institute, Via di Barbia/10, 40136 Bologna, Italy

c Institute for Microelectronics and Microsystems, National Research Council, Via Gobetti 101, 40129 Bologna, Italy

 

 

摘要:This work describes the preparation of keratin and chlorin e6-conjugated keratin nanoparticles, KNPs and KNPs@Ce6 respectively, by comparing self-assembling and desolvation methodologies. Nanoparticles were characterized in terms of yield, size, morphology, Ce6 loading ratio and ability to produce reactive oxygen species (ROS) upon irradiation with white light. Overall, both methods provided nanoparticles of comparable dimensions, morphology and Ce6 loading ratio. KNPs@Ce6 obtained by a self-assembling procedure were able to produce ROS in a concentration and irradiation-time dependent manner, while displaying compelling evidence of their photostability. In vitro internalization and photo-toxicity studies were performed on osteosarcoma (U2OS) and glioblastoma (U87) cells lines to assess the ability of KNPs@Ce6 nanoparticles to act as delivery systems for photodynamic therapy of cancer. Importantly, at all the Ce6 considered concentrations, e.g. 0.5, 2.5 and 5.0 μg mL−1, no dark toxicity was detected while the amount of Ce6 inside the cells, significantly increased when loaded onto KNPs. The irradiation of tumor cells loaded with KNPs@Ce6 resulted in a greater cell death percentage (approximay 90%) as compared to free Ce6 in both cell types and at all the considered concentrations, thus showing KNPs as effective and promising delivery vehicles for photodynamic therapy applications.

 

免責(zé)聲明

  • 凡本網(wǎng)注明“來源:化工儀器網(wǎng)”的所有作品,均為浙江興旺寶明通網(wǎng)絡(luò)有限公司-化工儀器網(wǎng)合法擁有版權(quán)或有權(quán)使用的作品,未經(jīng)本網(wǎng)授權(quán)不得轉(zhuǎn)載、摘編或利用其它方式使用上述作品。已經(jīng)本網(wǎng)授權(quán)使用作品的,應(yīng)在授權(quán)范圍內(nèi)使用,并注明“來源:化工儀器網(wǎng)”。違反上述聲明者,本網(wǎng)將追究其相關(guān)法律責(zé)任。
  • 本網(wǎng)轉(zhuǎn)載并注明自其他來源(非化工儀器網(wǎng))的作品,目的在于傳遞更多信息,并不代表本網(wǎng)贊同其觀點和對其真實性負責(zé),不承擔(dān)此類作品侵權(quán)行為的直接責(zé)任及連帶責(zé)任。其他媒體、網(wǎng)站或個人從本網(wǎng)轉(zhuǎn)載時,必須保留本網(wǎng)注明的作品第一來源,并自負版權(quán)等法律責(zé)任。
  • 如涉及作品內(nèi)容、版權(quán)等問題,請在作品發(fā)表之日起一周內(nèi)與本網(wǎng)聯(lián)系,否則視為放棄相關(guān)權(quán)利。
企業(yè)未開通此功能
詳詢客服 : 0571-87858618
康定县| 化州市| 山阳县| 侯马市| 江陵县| 康马县| 苍南县| 墨竹工卡县| 富顺县| 张家界市| 电白县| 类乌齐县| 平山县| 南京市| 三明市| 汝城县| 八宿县| 西吉县| 洞头县| 禄丰县| 杭锦后旗| 来安县| 利津县| 信丰县| 通山县| 五莲县| 新余市| 徐州市| 衡水市| 平乡县| 林周县| 泗水县| 库伦旗| 武宣县| 苍山县| 永善县| 洛宁县| 广南县| 灌南县| 龙门县| 安塞县|