AddaVax™
| 參考價 | ￥ 3465 |
| 訂貨量 | ≥1 件 |
- 公司名稱 深圳欣博盛生物科技有限公司
- 品牌 Invivogen
- 型號
- 產(chǎn)地 法國
- 廠商性質(zhì) 代理商
- 更新時間 2022/1/29 11:51:35
- 訪問次數(shù) 1696
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| 供貨周期 | 兩周 | 貨號 | vac-adx-10 |
|---|---|---|---|
| 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) | 主要用途 | 科研 |
Vaccine Adjuvant: Squalene-Oil-in-water
AddaVax™ is a squalene-based oil-in-water nano-emulsion with a formulation similar to that of MF59® that has been licensed in Europe for adjuvanted flu vaccines [1]. Squalene is an oil more readily metabolized than the paraffin oil used in Freund’s adjuvants [1]. Squalene oil-in-water emulsions, such as MF59®, elicit both cellular (Th1) and humoral (Th2) immune responses [2, 3].
This class of adjuvants is believed to act through recruitment and activation of APC and stimulation of cytokines and chemokines production by macrophages and granulocytes [1].
AddaVax™ is VacciGrade™ (preclinical grade) for research use only, not for use in humans.
MF59® is a registered trademark of Novartis, and is used for comparative purposes only. AddaVax™ is not made by, affiliated with, sponsored by or endorsed by Novartis. Novartis has not evaluated or approved the representations contained herein.
References:
1. Ott G. et al., 2000. The adjuvant MF59: a 10-year perspective. Methods in Molecular Medicine, Vol 42, 211-228.
2. Calabro, S. et al., 2013. The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. Vaccine 31:3363–9.
3. Ott G. et al., 1995. MF59. Design and evaluation of a safe and potent adjuvant for human vaccines. Pharm Biotechnol 6: 277-96.
Specifications
Specificity: Th1/Th2 response.
Working concentration: 1:1 (AddaVax™:antigen).
Quality control:
Sterility guaranteed.
Endotoxin level < 1 EU/ml.
Particle size ~ 160 nm.
Contents
10 ml AddaVax™, provided as a ready-to-use sterile emulsion.
AddaVax™ is shipped at room temperature.
Upon a receip it shouldbe stored at 4°C.
AddaVax™ is stable for 2 years.
DO NOT FREEZE.
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