国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

靶點科技(北京)有限公司

Broadpharm什么是電離脂質(zhì)Ionizable Lipids?

時間:2023-11-12閱讀:948

What are Ionizable Lipids

Ionizable lipids are a class of lipid molecules which remain neutral at physiological pH, but are protonated at low pH, making them positively charged, ALC-0315 (Figure 1) is an example with the amine site that can be protonated at low pH.


Figure 1: Structure of ALC-0315


Ionizable lipids are one key component of Ionizable lipid nanoparticles (LNPs) which have been widely used for the systemic delivery of RNA therapeutics. Other lipid molecules in LNPs include helper lipid, cholesterol, and PEG lipid, etc.

Commonly reported ionizable lipid materials were reported for LNP formulations include C12-200, cKK-E12, and DLin-MC3-DMA). These LNPs showed an efficient gene silencing in the liver at the dosing level of 0.002 mg of siRNA/kg.

Why use ionizable lipids?

The pH-sensitivity of ionizable lipids is beneficial for mRNA delivery in vivo, because neutral lipids have less interactions with the anionic membranes of blood cells which improves the biocompatibility of lipid nanoparticles. Trapped in endosomes, in which the pH is lower than the pH in the extracellular environment, ionizable lipids are protonated and become positively charged, which may promote membrane destabilization and facilitate endosomal escape of the nanoparticles. Ionizable Lipids promote endosome escape and reduce toxicity of lipid nanoparticles (LNP).

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research. 

Journal Reference:

1.X. Hou, T. Zaks, R. Langer, Y. Dong, "Nature Review Materials", (2021)

2.Y. Dong, K. Love, J. Dorkin, et.al.Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc. Natl. Acad. Sci. U.S.A. 111, 3955-3960 (2014).

會員登錄

X

請輸入賬號

請輸入密碼

=

請輸驗證碼

收藏該商鋪

X
該信息已收藏!
標簽:
保存成功

(空格分隔,最多3個,單個標簽最多10個字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時間回復(fù)您~

以上信息由企業(yè)自行提供,信息內(nèi)容的真實性、準確性和合法性由相關(guān)企業(yè)負責,化工儀器網(wǎng)對此不承擔任何保證責任。

溫馨提示:為規(guī)避購買風險,建議您在購買產(chǎn)品前務(wù)必確認供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。

撥打電話
在線留言
三都| 保康县| 饶阳县| 定兴县| 沂南县| 武威市| 长丰县| 乌兰浩特市| 汶川县| 沐川县| 尼勒克县| 鹿邑县| 隆昌县| 江口县| 阜康市| 澜沧| 崇明县| 榆树市| 青海省| 陵川县| 岐山县| 荔波县| 昭觉县| 乳山市| 太和县| 丰宁| 社旗县| 林州市| 平凉市| 抚州市| 波密县| 溧水县| 渑池县| 札达县| 西贡区| 塔河县| 林口县| 卢氏县| 昌黎县| 灵寿县| 深州市|