国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

靶點(diǎn)科技(北京)有限公司

Broadpharm什么是電離脂質(zhì)Ionizable Lipids?

時(shí)間:2023-11-12閱讀:954

What are Ionizable Lipids

Ionizable lipids are a class of lipid molecules which remain neutral at physiological pH, but are protonated at low pH, making them positively charged, ALC-0315 (Figure 1) is an example with the amine site that can be protonated at low pH.


Figure 1: Structure of ALC-0315


Ionizable lipids are one key component of Ionizable lipid nanoparticles (LNPs) which have been widely used for the systemic delivery of RNA therapeutics. Other lipid molecules in LNPs include helper lipid, cholesterol, and PEG lipid, etc.

Commonly reported ionizable lipid materials were reported for LNP formulations include C12-200, cKK-E12, and DLin-MC3-DMA). These LNPs showed an efficient gene silencing in the liver at the dosing level of 0.002 mg of siRNA/kg.

Why use ionizable lipids?

The pH-sensitivity of ionizable lipids is beneficial for mRNA delivery in vivo, because neutral lipids have less interactions with the anionic membranes of blood cells which improves the biocompatibility of lipid nanoparticles. Trapped in endosomes, in which the pH is lower than the pH in the extracellular environment, ionizable lipids are protonated and become positively charged, which may promote membrane destabilization and facilitate endosomal escape of the nanoparticles. Ionizable Lipids promote endosome escape and reduce toxicity of lipid nanoparticles (LNP).

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research. 

Journal Reference:

1.X. Hou, T. Zaks, R. Langer, Y. Dong, "Nature Review Materials", (2021)

2.Y. Dong, K. Love, J. Dorkin, et.al.Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc. Natl. Acad. Sci. U.S.A. 111, 3955-3960 (2014).

會(huì)員登錄

X

請(qǐng)輸入賬號(hào)

請(qǐng)輸入密碼

=

請(qǐng)輸驗(yàn)證碼

收藏該商鋪

X
該信息已收藏!
標(biāo)簽:
保存成功

(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時(shí)間回復(fù)您~

以上信息由企業(yè)自行提供,信息內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé),化工儀器網(wǎng)對(duì)此不承擔(dān)任何保證責(zé)任。

溫馨提示:為規(guī)避購(gòu)買風(fēng)險(xiǎn),建議您在購(gòu)買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。

撥打電話
在線留言
石景山区| 开江县| 玉龙| 滁州市| 沈丘县| 绵竹市| 荣成市| 民权县| 广德县| 内丘县| 内黄县| 河津市| 隆昌县| 屏东市| 华容县| 游戏| 延津县| 威远县| 新竹县| 广饶县| 郁南县| 比如县| 铜川市| 盐源县| 得荣县| 深水埗区| 赤峰市| 长岭县| 营口市| 牡丹江市| 金门县| 承德县| 夏河县| 广南县| 江陵县| 报价| 郴州市| 左权县| 丹巴县| 珲春市| 灵台县|