国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

靶點科技(北京)有限公司

Broadpharm什么是輔助脂質Helper Lipid?

時間:2023-11-12閱讀:982

What is a Helper Lipid?

Helper Lipids are a class of lipid molecules that increase particle stability and fluidity of lipid nanoparticles (LNP). Several classes of molecules were used as helper lipids such as phospholipids as exemplified by DSPC (Figure 1), cholesterol, PEGylated lipid.


Figure 1: Structure of DSPC


Benefits of Helper Lipids?

The main benefits using Helper lipids in Lipid nanoparticles (LNPs) delivery vehicles is to improve the properties of the nanoparticle, such as particle stability, delivery efficacy, tolerability and biodistribution.

For example, cholesterol can enhance particle stability by modulating membrane integrity and rigidity. The molecular geometry of cholesterol derivatives can further affect delivery efficacy and biodistribution of lipid nanoparticles. cholesterol analogues with C-24 alkyl phytosterols increases the in vivo delivery efficacy of lipid nanoparticle-mRNA formulations.

Helper lipids with a cone-shape geometry favoring the formation hexagonal II phase, such as dioleoyl phosphatidylethanolamine (DOPE), can promote endosomal release of ONs.

Cylindrical-shaped lipid phosphatidylcholine can provide greater bilayer stability, which is important for in vivo application of LNPs.

PEGylated lipids (PEG lipids) can enhance LNP colloidal stability and circulation time in vivo, but it might reduce uptake and inhibit endosomal release at the cellular level. This problem can be addressed by choosing reversible PEGylation in which the PEG moiety is gradually released in blood circulation.

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research. 

Journal Reference:

1. X Cheng, R. Lee, The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery, Adv Drug Deliv Rev, PMID: 26900977

會員登錄

X

請輸入賬號

請輸入密碼

=

請輸驗證碼

收藏該商鋪

X
該信息已收藏!
標簽:
保存成功

(空格分隔,最多3個,單個標簽最多10個字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時間回復您~

以上信息由企業(yè)自行提供,信息內容的真實性、準確性和合法性由相關企業(yè)負責,化工儀器網對此不承擔任何保證責任。

溫馨提示:為規(guī)避購買風險,建議您在購買產品前務必確認供應商資質及產品質量。

撥打電話
在線留言
商城县| 富裕县| 上高县| 耿马| 凯里市| 谢通门县| 即墨市| 平利县| 灯塔市| 永仁县| 铅山县| 呼图壁县| 景德镇市| 麟游县| 宁武县| 九龙坡区| 图木舒克市| 五峰| 合作市| 罗城| 岐山县| 慈利县| 凤冈县| 湟源县| 定日县| 驻马店市| 惠安县| 顺昌县| 淮南市| 上栗县| 屏东市| 沙坪坝区| 龙州县| 广平县| 皮山县| 上杭县| 易门县| 大城县| 嘉鱼县| 视频| 江山市|