国产精品视频一区二区三区四,亚洲av美洲av综合av,99国内精品久久久久久久,欧美电影一区二区三区电影

靶點(diǎn)科技(北京)有限公司

Broadpharm什么是輔助脂質(zhì)Helper Lipid?

時間:2023-11-12閱讀:993

What is a Helper Lipid?

Helper Lipids are a class of lipid molecules that increase particle stability and fluidity of lipid nanoparticles (LNP). Several classes of molecules were used as helper lipids such as phospholipids as exemplified by DSPC (Figure 1), cholesterol, PEGylated lipid.


Figure 1: Structure of DSPC


Benefits of Helper Lipids?

The main benefits using Helper lipids in Lipid nanoparticles (LNPs) delivery vehicles is to improve the properties of the nanoparticle, such as particle stability, delivery efficacy, tolerability and biodistribution.

For example, cholesterol can enhance particle stability by modulating membrane integrity and rigidity. The molecular geometry of cholesterol derivatives can further affect delivery efficacy and biodistribution of lipid nanoparticles. cholesterol analogues with C-24 alkyl phytosterols increases the in vivo delivery efficacy of lipid nanoparticle-mRNA formulations.

Helper lipids with a cone-shape geometry favoring the formation hexagonal II phase, such as dioleoyl phosphatidylethanolamine (DOPE), can promote endosomal release of ONs.

Cylindrical-shaped lipid phosphatidylcholine can provide greater bilayer stability, which is important for in vivo application of LNPs.

PEGylated lipids (PEG lipids) can enhance LNP colloidal stability and circulation time in vivo, but it might reduce uptake and inhibit endosomal release at the cellular level. This problem can be addressed by choosing reversible PEGylation in which the PEG moiety is gradually released in blood circulation.

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research. 

Journal Reference:

1. X Cheng, R. Lee, The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery, Adv Drug Deliv Rev, PMID: 26900977

會員登錄

X

請輸入賬號

請輸入密碼

=

請輸驗(yàn)證碼

收藏該商鋪

X
該信息已收藏!
標(biāo)簽:
保存成功

(空格分隔,最多3個,單個標(biāo)簽最多10個字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時間回復(fù)您~

以上信息由企業(yè)自行提供,信息內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé),化工儀器網(wǎng)對此不承擔(dān)任何保證責(zé)任。

溫馨提示:為規(guī)避購買風(fēng)險,建議您在購買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。

撥打電話
在線留言
伊宁县| 临颍县| 德江县| 二连浩特市| 嘉善县| 定远县| 庄河市| 东港市| 霍邱县| 永平县| 龙胜| 即墨市| 太谷县| 岚皋县| 枝江市| 永济市| 南召县| 容城县| 万盛区| 白银市| 霍州市| 泾阳县| 蓝田县| 鄂伦春自治旗| 岚皋县| 石河子市| 广东省| 綦江县| 丰都县| 祁阳县| 黎川县| 海门市| 新昌县| 新田县| 旌德县| 乳源| 大新县| 依兰县| 平罗县| 贵阳市| 武汉市|